Sökning: "single-cell omics"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden single-cell omics.

  1. 1. Host-parasite interactions in space and time

    Författare :Franziska Hildebrandt; Johan Ankarklev; Volker T. Heussler; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Malaria; liver-stage infection; Toxoplasma; host-parasite interactions; spatial transcriptomics; single-cell omics; single-cell Dual-seq; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : Unicellular parasites of the apicomplexan phylum have a considerable effect on global health and agriculture. Two prominent examples of this phylum include malaria causing parasites of the Plasmodium genus and the widely prevalent parasite Toxoplasma gondii. LÄS MER

  3. 2. Integrative Modeling of Epigenetic Regulation in Human Disease

    Författare :Xi Lu; Xingqi Chen; Chandrasekhar Kanduri; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioblastoma; Cross-species; Glioblastoma stem cell; Dravet syndrome; ATAC-seq; Single-cell multi-omics technology;

    Sammanfattning : Glioblastoma is the most common and aggressive primary brain tumor. Standard of treatment prove ineffective, leading to tumor recurrence and an average survival rate of 14 months. This treatment resistance is attributed to both inter-tumor and intra-tumor heterogeneity observed across diverse tumor samples and within individual cells. LÄS MER

  4. 3. Kidney diseases : insights from omics approaches

    Författare :Jing Guo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic kidney diseases (CKDs) affects about 11-15% of adults worldwide. When it progresses to the end-stage renal disease (ESRD), there is no effective medication for cure, the only treatment being chronic dialysis or kidney transplantation. LÄS MER

  5. 4. Integrative omics data analysis to discover novel signatures in complex diseases

    Författare :Lu Pan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Apart from diseases caused by the defect of a single gene, most diseases are highly complex and are usually caused by a combination of biological and environmental factors. In the biological context, cellular processes are often tightly connected across molecular layers of the central dogma of biology, and the examination of a single layer would not be sufficient to address disease pathology, therefore, conclusions drawn can be limited. LÄS MER

  7. 5. Towards spatial host-microbiome profiling

    Författare :Britta Lötstedt; Joakim Lundeberg; Petri Auvinen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 16S sequencing; RNA sequencing; spatially resolved transcriptomics; antibody-based measurements; Bioteknologi; Biotechnology;

    Sammanfattning : Sequencing technologies and applications have pushed the limits and enabled novel studies of biological mechanisms, evolutionary relationships and communication networks between cells. The technical developments leading to single cell RNA-sequencing have enabled detection of rare cell populations while spatial resolution added insights into larger biological environments, like tissues and organs. LÄS MER