Sökning: "Endokrinologi diabetology sekretion diabetologi secreting systems Endocrinology beta-cell diabetes i"

Visar resultat 6 - 10 av 16 avhandlingar innehållade orden Endokrinologi diabetology sekretion diabetologi secreting systems Endocrinology beta-cell diabetes i.

1. 6. The Role of Phosphodiesterase 3B in the Regulation of Insulin Secretion

   Författare :Linda Härndahl; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; beta-cell; diabetes; islet; PDE3B; cAMP;

   Sammanfattning : Pancreatic beta-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes. An early sign of beta-cell dysfunction is impaired nutrient-induced insulin release. Several insulin secretagogues act by increasing the formation of intracellular cAMP. LÄS MER

3. 7. Beta cell function in autoimmune diabetes in young adults

   Författare :Carina Törn; Celiaki och diabetes; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ketoacidosis; insulin treatment; prognostic factors; C-peptide; type 2; type 1; IA-2A; ICA; GADA; IAA; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : This thesis presents the results from a study of the first four years of diabetes in 879 patients aged 15-34 years at diagnosis. The aims of this study were to compare clinical classification with the presence of autoantibodies, to study the natural course of beta cell function during the first years of disease and to define predictive factors for the remaining beta cell function after diagnosis. LÄS MER

4. 8. Expression and Regulation of Neuropeptide Y (NPY) in the Islets of Langerhans

   Författare :Ulrika Myrsén Axcrona; Neuroendokrin cellbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; regulatory peptides; diabetes; glucocorticoids; beta cell; islet hormones; neuropeptide Y; insulin; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : This thesis deals with the expression, localization and regulation of neuropeptide Y (NPY) in the pancreatic islets of Langerhans under normal and experimental conditions. NPY is widely distributed in the mammalian nervous system and belongs to a family of closely related petides also comprising peptide YY (PYY) and pancreatic polypeptide (PP). LÄS MER

5. 9. On Cholecystokinin and Phospholipase A2 in Insulin Secretion - an Experimental Study With Reference to the Development of Diabetes

   Författare :Erik Simonsson; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 Diabetes; Insulin Resistance; Islet; Beta-cell; Insulin Secretion; Ca2 -Dependency; Intracellular Signalling; Phospholipase A2; Cholecystokinin; Non-glucose Secretagogues; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : In view of unsolved issues regarding cellular events underlying the adaptation of insulin secretion to insulin resistance, together with the observation that insulin secretion induced by the gastrointestinal hormone and neuropeptide cholecystokinin (CCK) is not solely explained by phospholipase C-protein kinase C (PLC-PKC) pathway activation, this study aimed at delineate mechanisms responsible for the hyperinsulinemia in insulin resistance, with particular attention paid to the action of glucose vs. non-glucose secretagogues, such as CCK. LÄS MER

7. 10. Type 2 Diabetes in a Defined Population The Skaraborg Hypertension and Diabetes Project

   Författare :Carl Johan Östgren; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; HOMA; primary care; all-cause mortality; Pro12Ala; PPAR-gamma; survival; insulin resistance; beta-cell function; type 2 diabetes; hypertension; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : To examine cardiovascular risk factors, glycaemic control and survival in patients with type 2 diabetes mellitus (T2DM) treated in primary care, patients with T2DM and a randomised age-stratified sample of men and women aged ≥40 years living in the same community were surveyed 1992-1994. ß–Cell function and insulin resistance were estimated using the Homeostasis Model Assessment (HOMA). LÄS MER