Sökning: "PPAR-gamma"
Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet PPAR-gamma.
1. Type 2 Diabetes in a Defined Population The Skaraborg Hypertension and Diabetes Project
Sammanfattning : To examine cardiovascular risk factors, glycaemic control and survival in patients with type 2 diabetes mellitus (T2DM) treated in primary care, patients with T2DM and a randomised age-stratified sample of men and women aged ≥40 years living in the same community were surveyed 1992-1994. ß–Cell function and insulin resistance were estimated using the Homeostasis Model Assessment (HOMA). LÄS MER
2. STAT5 expression and regulation in mammary epithelial cells
Sammanfattning : The mammary gland of an adult mammal undergoes cycles of proliferation and differentiation influenced by growth factors, peptide, and steroid hormones, e.g. epidermal growth factor (EGF), prolactin (PRL) and estrogen (E). LÄS MER
3. Mechanisms regulating metabolic and mitogenic events in skeletal muscle : implications for insulin resistance and exercise
Sammanfattning : Reduced glucose transport in skeletal muscle is a hallmark feature of Type II diabetes. Numerous mechanisms acutely or chronically regulate skeletal muscle glucose transport. The role of GLUT4, mitogen-activated protein kinases (MAPK), and peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) were examined in skeletal muscle. LÄS MER
4. Approaches for the localization and identification of human cancer genes
Sammanfattning : Chromosomal aberrations have been recognized as important observations that underpin the concept of a mutator phenotype in cancer. In this thesis, two basic strategies were applied to map the location of cancer-related genes in several types of cancers. LÄS MER
5. Identification of natural activators of the nuclear receptor peroxisome proliferator-activated receptor : relevance to the pathogenesis of atherosclerosis
Sammanfattning : Polyunsaturated fatty acids induce peroxisome proliferation. This phenomenon is mediated by the ligand-dependent transcription factor peroxisome proliferator-activated receptor (PPAR). This thesis is an investigation on the role of eicosanoids and oxidized products of linoleic acid for the activation of PPARs. LÄS MER