Sökning: "glucocorticoids"

Visar resultat 1 - 5 av 144 avhandlingar innehållade ordet glucocorticoids.

  1. 1. Modulators of UCP1-dependent thermogenesis : Glucocorticoids, diet and novel research models

    Författare :Ineke H. N. Luijten; Jan Nedergaard; Onno Meijer; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; brown adipose tissue; UCP1; glucocorticoids; diet-induced thermogenesis; obesity; physiology; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The activation and recruitment of brown adipose tissue (BAT) thermogenesis has been put forward as a promising strategy to reduce the disease burden of obesity and obesity-related diseases. Heat production by BAT can be attributed to the tissue-specific mitochondrial uncoupling protein 1 (UCP1). LÄS MER

  2. 2. Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation

    Författare :Karin Gewert; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; signal transduction; dexamethasone; cytosolic phospholipase A2; glucocorticoids; macrophages; protein kinase C; mitogen-activated protein kinases; TNF-alpha; IL-1beta; protein phosphatases; okadaic acid; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Sammanfattning : The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. LÄS MER

  3. 3. Experimental studies on the effects of insulin-like growth factor I and glucocorticoids on bone metabolism

    Författare :Kenneth B. Jonsson; Uppsala universitet; []
    Nyckelord :Medical sciences; Bone; bone resorption; glucocorticoids; insulin-like growth factor I; osteoblasts; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicine; medicin;

    Sammanfattning : Osteoporosis is a major cause of disability among patients that are dependent on glucocorticoids in the treatment of inflammatory disease. The pathogenesis behind this side effect is complex, involving dysregulation of hormonal systems and direct effects on bone cells. LÄS MER

  4. 4. Disease activity in rheumatoid arthritis : Studies in interleukin-6, tumour necrosis factor alpha, monocyte activity, acute phase markers, glucocorticoids, and disability

    Författare :Nils Gunnar Arvidson; Anders Larsson; Arvi Larsen; Øystein Førre; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; Chemistry; acute phase markers; circadian rhythm; disability; disease activity; glucocorticoids; monocyte activation; rheumatoid arthritis; Kemi; Chemistry; Kemi; Medicine; medicin;

    Sammanfattning : In the present studies, aspects of some disease activity measures in rheumatoid arthritis (RA) have been investigated, including the effect of glucocorticoids on this activity. In RA, serum interleukin(IL)-6 levels were elevated and were shown to have a circadian rhythm, with peak levels in the morning, declining towards low or normal levels in the afternoon and evening. LÄS MER

  5. 5. Laminins and Fibulins in Bone Marrow

    Författare :Yu-Chen Gu; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucocorticoids; integrin; Immunology; serology; Immunologi; serologi; transplantation; Cytology; oncology; Biokemi; Metabolism; Biochemistry; cancer; onkologi; cancerology; Cytologi; fibulin; laminin; bone marrow;

    Sammanfattning : Development of hematopoietic cells in bone marrow takes place in association with the hematopoietic microenvironment. Extracellular matrix (ECM) molecules and stromal cells in bone marrow provide a structural environment for hematopoietic cells, but they also directly influence proliferation, differentiation and migration of cells by signal transduction mediated by ligand binding to cell surface adhesion receptors. LÄS MER