Sökning: "Intracellular Signalling"

Visar resultat 1 - 5 av 170 avhandlingar innehållade orden Intracellular Signalling.

  1. 1. β-adrenergic stimulation of VEGF gene expression : intracellular signalling pathways

    Detta är en avhandling från Stockholm : Stockholm University

    Författare :Magnus J. Fredriksson; Stockholms universitet.; [2001]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; zoofysiologi; Zoological physiology;

    Sammanfattning : In the present study, the intracellular signalling pathway mediating ß-adrenergic stimulation of the expression of the vascular endothelial growth factor (VEGF) gene was investigated.VEGF is an activator of angiogenesis, the formation of new blood vessels, and is considered to be a major regulator of both physiologically and pathologically related angiogenesis, as well as being essential for development of the vascular system. LÄS MER

  2. 2. Notch signalling in carcinogenesis With special emphasis on T-cell lymphoma and colorectal cancer

    Detta är en avhandling från Stockholm : Stockholm University

    Författare :Jonas Ungerbäck; Peter Söderkvist; Ola Hermanson; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Notch signalling; T-cell lymphoma; colorectal cancer; Wnt signalling; transcription; MEDICINE Morphology; cell biology; pathology Cell biology Medical cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi Medicinsk cellbiologi;

    Sammanfattning : The Notch signalling pathway is an evolutionary conserved pathway, named after the Notch receptors, Notch1-4 in mammals, which upon cell-cell contact and ligand binding releases the intracellular domain (NICD). NICD translocates into the nucleus where it binds the transcriptional repressor RBP-Jk, which together with co-activators belonging to the Mastermind-like family of proteins form a transcriptional activation complex. LÄS MER

  3. 3. Platelets : intracellular signalling and cellular interaction

    Detta är en avhandling från Linköping : Linköpings universitet

    Författare :Magnus Grenegård; Linköpings universitet.; Linköpings universitet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICINE; MEDICIN;

    Sammanfattning : Activation of platelets is essential to prevent excessive blood loss at the site of vascular injury. These highly reactive cell fragments are also involved in several pathological conditions, in particular arterial thrombosis, which, in the coronary vessels, can lead to reduced blood flow, vessel occlusion and myocardial infarction. LÄS MER

  4. 4. Injury-Induced Signalling in Arterial Smooth Muscle Cells

    Detta är en avhandling från Sara Moses, Lund University, Dept. Cell and Molecular Biology, BMC C12, 221 84 Lund

    Författare :Sara Moses; Lund University.; Lunds universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GAG; Clinical biology; Klinisk biologi; proteoglycan; osteopontin; ERK; MAPK; signalling; smooth muscle cell; injury;

    Sammanfattning : The vascular wall is an active, elastic and integrated organ made up of cellular and extracellular matrix (ECM) components. It is not a static organ; the components dynamically change and reorganize in response to physiological and pathological stimuli. Vascular injury induces a complex healing process, analogous to generalised wound healing. LÄS MER

  5. 5. Regulation of morphogen signalling during neural patterning in the Xenopus embryo

    Detta är en avhandling från Department of Laboratory Medicine, Lund University

    Författare :Hooi Min Tan Grahn; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Suppressor-of-fused; Gli; β-Catenin; Neural; Xenopus; FGF; Signalling; HtrA1; RDH10; Retinol dehydrogenase; Retinoic acid; Spemann s organizer; Induction; Gradient;

    Sammanfattning : Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xenopus embryo. LÄS MER