Sökning: "Electrospray ionization"

Visar resultat 16 - 20 av 84 avhandlingar innehållade orden Electrospray ionization.

1. 16. Identification and Characterization of Peptides and Proteins using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

   Författare :Magnus Palmblad; Ole Nørregaard Jensen; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Materials science; Peptide; protein; peptide mass fingerprinting; identification; sequencing; protein structure; non-covalent interaction; modification; electrospray ionization; liquid chromatography; capillary electrophoresis; electron capture dissociation; Fourier transform ion cyclotron resonance mass spectrometry; cerebrospinal fluid; amyloid β-peptide; Alzheimer’s disease.; Materialvetenskap; Materials science; Teknisk materialvetenskap; Molecular Biotechnology; Molekylär bioteknik;

   Sammanfattning : Mass spectrometry has in recent years been established as the standard method for protein identification and characterization in proteomics with excellent intrinsic sensitivity and specificity. Fourier transform ion cyclotron resonance is the mass spectrometric technique that provides the highest resolving power and mass accuracy, increasing the amount of information that can be obtained from complex samples. LÄS MER

3. 17. Liquid Chromatography Coupled to Mass Spectrometry : Implementation of Chemometric Optimization and Selected Applications

   Författare :My Moberg; Jonas Bergquist; Karin E. Markides; Dan Bylund; Douglas B. Kell; Uppsala universitet; []
   Nyckelord :Analytical chemistry; liquid chromatography; mass spectrometry; tandem mass spectrometry; electrospray ionization; inductively coupled plasma; chemometrics; optimization; multivariate data analysis; design of experiments; response surface model; siderophore; azathioprine; peptide; Analytisk kemi;

   Sammanfattning : Liquid chromatography (LC) coupled to mass spectrometry (MS) offers highly selective and sensitive analysis of a wide variety of compounds. However, the use of hyphenated experimental set-ups implies that many parameters may have an effect on the studied response. LÄS MER

4. 18. Advances in Mass Spectrometry for the Analysis of Emerging Persistent Organic Pollutants

   Författare :Lauren Gayle Mullin; Leo W. Y. Yeung; Ingrid Ericson Jogsten; Jean-François Focant; Örebro universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mass Spectrometry; Liquid Chromatography; Supercritical Fluid Chromatography; Ion Mobility; POPs; Electrospray Ionization;

   Sammanfattning : Mass spectrometry (MS) is a technique widely implemented for the measurement of environmental pollutants. A critical tool for the analysis of persistent organic pollutants (POPs) over several decades, MS as coupled with liquid and gas chromatography (LC and GC) techniques enables the analysis of emerging POPs. LÄS MER

5. 19. Development of Capillary Electrophoresis Methods Coupled to Mass Spectrometry for Biomedical and Pharmaceutical Analysis

   Författare :Anisa Elhamili; Jonas Bergquist; Magnus Wetterhall; Douglas Westerlund; Alejandro Cifuentes; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Capillary Electrophoresis; Capillary Surface Modificaions; Electrospray Ionization; Mass Spectrometry; Peptides; Intact Proteins; Basic Pharmaceutical Drug Molecules and Complex Biological Samples; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

   Sammanfattning : The analysis of large intact proteins and complex biological samples containing drug molecules is a common complicated task for many scientists. However, due to the importance of these molecules, there is a growing interest in pharmaceutical and medicinal research to develop rapid, highly sensitive and efficient analytical techniques. LÄS MER

7. 20. Development of Enhanced Analytical Methodology for Lipid Analysis from Sampling to Detection : A Targeted Lipidomics Approach

   Författare :Giorgis Isaac; Jonas Bergquist; Karin Markides; Monica Waldebäck; William Christie; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; electrospray ionization; lipids; liquid chromatography; mass spectrometry; pesticides; phosphatidylcholine; pressurized fluid extraction; sphingomyelin; sulfatides; Analytisk kemi; Analytical chemistry; Analytisk kemi;

   Sammanfattning : This thesis covers a wide range of analytical method development for lipid analysis in complex biological samples; from sample preparation using pressurized fluid extraction (PFE) and separation with reversed phase capillary liquid chromatography (RP-LC) to detection by electrospray ionization mass spectrometry (ESI/MS) and tandem MS.The requirements for fast, reliable and selective extraction methods with minimal usage of solvents have accelerated the development of new extraction techniques. LÄS MER