Sökning: "Douglas Westerlund"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Douglas Westerlund.

  1. 1. Studies on the fluorimetric determination of subnanomole amounts of ammonium compounds by ion-pair extraction with application to bioanalysis

    Författare :Douglas Westerlund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  3. 2. Development of Capillary Electrophoresis Methods Coupled to Mass Spectrometry for Biomedical and Pharmaceutical Analysis

    Författare :Anisa Elhamili; Jonas Bergquist; Magnus Wetterhall; Douglas Westerlund; Alejandro Cifuentes; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Capillary Electrophoresis; Capillary Surface Modificaions; Electrospray Ionization; Mass Spectrometry; Peptides; Intact Proteins; Basic Pharmaceutical Drug Molecules and Complex Biological Samples; Chemistry; Kemi; Analytical Chemistry; Analytisk kemi;

    Sammanfattning : The analysis of large intact proteins and complex biological samples containing drug molecules is a common complicated task for many scientists. However, due to the importance of these molecules, there is a growing interest in pharmaceutical and medicinal research to develop rapid, highly sensitive and efficient analytical techniques. LÄS MER

  4. 3. Aspects of Optimisation of Separation of Drugs by Chemometrics

    Författare :Valérie Harang; Douglas Westerlund; Sven P. Jacobsson; Bo Karlberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; optimisation; separation; chemometrics; high performance liquid chromatography; electrodriven techniques; microemulsion electrokinetic chromatography; statistical experimental design; molecular modelling; chiral separation; cellobiohydrolase; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

    Sammanfattning : Statistical experimental designs have been used for method development and optimisation of separation. Two reversed phase HPLC methods were optimised. LÄS MER

  5. 4. Separation of Proteins with Capillary Electrophoresis in Coated Capillaries with and without Electroosmosis : Studies on Zone Broadening and Analytical Performances

    Författare :Sheila Mohabbati; Douglas Westerlund; Bo Karlberg; Uppsala universitet; []
    Nyckelord :Pharmaceutical chemistry; Capillary electrophoresis; capillary coatings; proteins; zone broadening; zone sharpening; efficiency; resolution; protein-surface adsorption; protein-buffer interaction; analytical performance; Farmaceutisk kemi;

    Sammanfattning : Proteins have such structural features that they may interact with different types of surfaces by all possible forces, i.e., electrostatic, hydrogen bonding, hydrophobic. In this thesis two different types of coatings for fused silica capillaries aimed to eliminate such interactions have been studied. LÄS MER

  7. 5. Liquid Chromatography-Mass Spectrometry as a Tool for Drug Metabolite Identification in Biological Fluids : With Application to Ketobemidone

    Författare :Ingela Sundström; Per Andrén; Douglas Westerlund; Monika Johansson; Uppsala universitet; []
    Nyckelord :Analytical chemistry; LC-MS MS; accurate mass measurement; drug metabolites; microdialysate; brain; fluorinated stationary phase; phenylboronic acid; retention mechanism; Analytisk kemi;

    Sammanfattning : Electrospray ionization (ESI) mass spectrometry (MS) in combination with liquid chromatography (LC) is an excellent tool for the identification of drug metabolites. Utilizing this hyphenated technique in combination with proper sample pretreatment, the metabolic pathways of the analgesic drug ketobemidone were investigated in human urine and rat microdialysate from blood and brain. LÄS MER