Sökning: "amyloid β-peptide"

Visar resultat 1 - 5 av 29 avhandlingar innehållade orden amyloid β-peptide.

  1. 1. NMR studies on interactions between the amyloid β peptide and selected molecules

    Författare :Anna Wahlström; Astrid Gräslund; Göran Karlsson; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Amyloid β peptide; Alzheimer s disease; Aggregation; Oligomer; Amyloid; Interaction; Nuclear Magnetic Resonance Spectroscopy; Circular Dichroism Spectroscopy; Thioflavin T; Detergent; Congo red; Affibody; Cyclodextrin dimer; Metal ion; Chemistry; Kemi; Biochemistry; Biokemi; Biophysics; biofysik;

    Sammanfattning : Alzheimer’s disease is an incurable neurodegenerative disorder linked to the amyloid β (Aβ) peptide, a 38-43 residue peptide. The detailed molecular disease mechanism(s) is (are) unknown, but oligomeric Aβ structures are proposed to be involved. LÄS MER

  2. 2. On the molecular mechanisms of the amyloid β-peptide aggregation

    Författare :Kalyani Sanagavarapu; NanoLund; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein aggregation; amyloid β-peptide; aggregation kinetics; aggregation mechanism N-terminus; mutations; variants; sequence determinants; ; cross-seeding;

    Sammanfattning : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. LÄS MER

  3. 3. Modulation of amyloid β peptide self-assembly : Aggregation mechanisms associated with Alzheimer's disease

    Författare :Axel Abelein; Astrid Gräslund; Magnus Wolf-Watz; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biophysics; biofysik;

    Sammanfattning : .... LÄS MER

  4. 4. Self-assembly of amyloid-β peptides in the presence of metal ions and interacting molecules – a detour of amyloid building blocks

    Författare :Cecilia Mörman; Astrid Gräslund; Daniel Otzen; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; biophysics; Alzheimer’s disease; protein aggregation; amyloid formation; amyloid-β peptide; aggregation kinetics; interactions; metal ions; designed peptide constructs; Tau protein; NMR; circular dichroism; fluorescence spectroscopy; Biophysics; biofysik;

    Sammanfattning : Misfolding of proteins into amyloid structures is implicated as a pathological feature in several neurodegenerative diseases and the molecular causes are still unclear. One typical characteristic of Alzheimer’s disease is self-assembly and accumulation of soluble amyloid-β (Aβ) peptides into insoluble fibrils and plaques. LÄS MER

  5. 5. Processing of the amyloid precursor protein and its paralogues amyloid precursor-like proteins 1 and 2

    Författare :Linda Adlerz; Kerstin Iverfeldt; Richard Cowburn; Stockholms universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; Alzheimer s disease; Amyloid β-peptide; Processing; RA; BDNF; IGF-1; curcumin; PI3-K; MAPK; cdk5; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. LÄS MER