Sökning: "Dosing"
Visar resultat 6 - 10 av 156 avhandlingar innehållade ordet Dosing.
6. Using Pharmacokinetic and Pharmacodynamic Principles to Evaluate Individualisation of Antibiotic Dosing – Emphasis on Cefuroxime
Sammanfattning : Cefuroxime is a renally eliminated antibiotic used against a variety of different bacterial infections. The pharmacokinetics (PK) for cefuroxime was studied in 97 hospitalized patients using population analysis. To be able to measure cefuroxime in human serum a new sensitive analytical method was developed using mass spectrometry detection. LÄS MER
7. Optimizing levodopa dosing routines for Parkinson’s disease
Sammanfattning : This thesis in the field of microdata analysis aims to introduce dose optimizing algorithms for the pharmacological management of Parkinson’s disease (PD). PD is a neurodegenerative disease that mostly affects the motor functions of the patients and it is characterized as a movement disorder. LÄS MER
8. Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies
Sammanfattning : Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. LÄS MER
9. Major determinants of outcome and dosing in warfarin treatment
Sammanfattning : The aim of this thesis was to identify factors that determine individual patients sensitivity to the anticoagulant warfarin, and to quantify the effect of such factors on different measures of anticoagulation control. As part of this project, a large bio-bank was prospectively collected, with DNA and clinical data from more than 1500 patients starting warfarin treatment (the WARG cohort). LÄS MER
10. On the Prediction of Warfarin Dose
Sammanfattning : Warfarin is one of the most widely used anticoagulants in the world. Treatment is complicated by a large inter-individual variation in the dose needed to reach adequate levels of anticoagulation i.e. INR 2. LÄS MER