Sökning: "PK PD indices"
Hittade 4 avhandlingar innehållade orden PK PD indices.
1. Pharmacometric Models for Antibacterial Agents to Improve Dosing Strategies
Sammanfattning : Antibiotics are among the most commonly prescribed drugs. Although the majority of these drugs were developed several decades ago, optimal dosage (dose, dosing interval and treatment duration) have still not been well defined. LÄS MER
2. Mechanism-Based Pharmacokinetic and Pharmacodynamic Modelling of Paclitaxel
Sammanfattning : Paclitaxel (Taxol®) is now widely used against breast, ovarian and non-small-cell lung cancer. Anticancer agents generally have narrow therapeutic indices, often with myelosuppression (mainly neutropenia) as dose-limiting side effect. LÄS MER
3. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres
Sammanfattning : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. LÄS MER
4. Biological and Pharmacological Factor that Influence the Selection of Antibiotic Resistance
Sammanfattning : Antibiotic treatment causes an ecological disturbance on the human microflora. Four commensal bacteria: E. coli, enterococci, a-streptococci and coagulase-negative staphylococci, from patients with extensive, high antibiotic usage were investigated with regard to resistance pattern and mutation frequency. LÄS MER