Sökning: "Dosing algorithm"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Dosing algorithm.

  1. 1. Automating levodopa dosing schedules for Parkinson’s disease

    Författare :Ilias Thomas; Jerker Westin; Moudud Alam; Björn Eskofier; Högskolan Dalarna; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Parkinson’s disease; levodopa; symptom assessment; symptom management; dosing algorithms; wearable sensors; microtablets; continuous infusion; FLOAT - Flexible Levodopa Optimizing Assistive Technology; FLOAT - Flexibel levodopa-optimerings och individanpassningsteknik;

    Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disease. Levodopa is mainly used to manage the motor symptoms of PD. However, disease progression and long-term use of levodopa cause reduced medication efficacy and side effects. When that happens, precise individualized dosing schedules are required. LÄS MER

  3. 2. On the Prediction of Warfarin Dose

    Författare :Niclas Eriksson; Mia Wadelius; Lars Wallentin; Lars Berglund; Patrik Magnusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Warfarin; pharmacogenetics; prediction models; Dosing algorithm; GWAS; VKORC1; CYP2C9; Clinical Pharmacology; Klinisk farmakologi;

    Sammanfattning : Warfarin is one of the most widely used anticoagulants in the world. Treatment is complicated by a large inter-individual variation in the dose needed to reach adequate levels of anticoagulation i.e. INR 2. LÄS MER

  4. 3. Optimizing levodopa dosing routines for Parkinson’s disease

    Författare :Ilias Thomas; Jerker Westin; Moudud Alam; Alexander Medvedev; Högskolan Dalarna; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Parkinson’s disease; levodopa; symptom assessment; symptom management; dosing algorithms; wearable sensors; microtablets; continuous infusion; FLOAT - Flexible Levodopa Optimizing Assistive Technology; FLOAT - Flexibel levodopa-optimerings och individanpassningsteknik;

    Sammanfattning : This thesis in the field of microdata analysis aims to introduce dose optimizing algorithms for the pharmacological management of Parkinson’s disease (PD). PD is a neurodegenerative disease that mostly affects the motor functions of the patients and it is characterized as a movement disorder. LÄS MER

  5. 4. Garnishing the smorgasbord of pharmacometric methods

    Författare :Henrik Bjugård Nyberg; Andrew Hooker; Johannes Schropp; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; saddle points; nonidentifiability; modelling and simulation; tuberculosis; ethionamide; bioequivalence; model-integrated evidence; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The smorgasbord of methods that we use within the field of pharmacometrics has developed steadily over several decades and is now a well-laid-out buffet. This thesis adds some garnish to the table in the form of small improvements to the handling of certain problems. LÄS MER

  7. 5. Coagulation during and after cardiopulmonary bypass with focus on heparin, protamine, aprotinin and platelet function

    Författare :Gunilla Kjellberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Heparin and protamine dosing for anticoagulation during cardiopulmonary bypass (CPB) and its reversal after CPB, respectively, is usually given according to body weight. Excess protamine may impair coagulation. The HeProCalc algorithm calculates heparin and protamine doses during the procedure. LÄS MER