Sökning: "dosing algorithms"

Hittade 5 avhandlingar innehållade orden dosing algorithms.

  1. 1. Automating levodopa dosing schedules for Parkinson’s disease

    Författare :Ilias Thomas; Jerker Westin; Moudud Alam; Björn Eskofier; Högskolan Dalarna; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Parkinson’s disease; levodopa; symptom assessment; symptom management; dosing algorithms; wearable sensors; microtablets; continuous infusion; FLOAT - Flexible Levodopa Optimizing Assistive Technology; FLOAT - Flexibel levodopa-optimerings och individanpassningsteknik;

    Sammanfattning : Parkinson’s disease (PD) is the second most common neurodegenerative disease. Levodopa is mainly used to manage the motor symptoms of PD. However, disease progression and long-term use of levodopa cause reduced medication efficacy and side effects. When that happens, precise individualized dosing schedules are required. LÄS MER

  3. 2. Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia

    Författare :Peter Jönsson; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; high dose methotrexate; exposure; dosing algorithms; renal function; cerebrospinal fluid; childhood acute lymphoblastic leukaemia; population pharmacokinetics; relapse risk;

    Sammanfattning : Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most contemporary childhood ALL treatment protocols. LÄS MER

  4. 3. Optimizing levodopa dosing routines for Parkinson’s disease

    Författare :Ilias Thomas; Jerker Westin; Moudud Alam; Alexander Medvedev; Högskolan Dalarna; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Parkinson’s disease; levodopa; symptom assessment; symptom management; dosing algorithms; wearable sensors; microtablets; continuous infusion; FLOAT - Flexible Levodopa Optimizing Assistive Technology; FLOAT - Flexibel levodopa-optimerings och individanpassningsteknik;

    Sammanfattning : This thesis in the field of microdata analysis aims to introduce dose optimizing algorithms for the pharmacological management of Parkinson’s disease (PD). PD is a neurodegenerative disease that mostly affects the motor functions of the patients and it is characterized as a movement disorder. LÄS MER

  5. 4. Pharmacometrics to improve evaluation and individualization of anticancer drug treatment

    Författare :Sreenath Madathil Krishnan; Lena Friberg; Mats Karlsson; Zinnia Parra Gillén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacodynamics; survival modeling;

    Sammanfattning : The success rate in clinical development of newer anti-cancer molecules is the lowest compared to other major diseases. Improving the success rate and better early evaluation of efficacy of anti-cancer drugs remain challenging obstacles. LÄS MER

  7. 5. Selective laser sintering for 3D printing of medications

    Författare :Evgenii Tikhomirov; Jonas Lindh; Julian Quodbach; Maria Strömme; Ocean Cheung; Jarkko Ketolainen; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Additive manufacturing; 3D printing; Selective laser sintering; Personalized medicines; Drug manufacturing; Teknisk fysik med inriktning mot nanoteknologi och funktionella material; Engineering Science with specialization in Nanotechnology and Functional Materials;

    Sammanfattning : Suboptimal treatment caused by inaccurate dosing of prescribed medications is a challenging issue for the pharmaceutical industry. As a result, certain groups of patients, especially pediatric patients, may suffer from a lack of specific dosage forms, leading to potential side effects. LÄS MER