Sökning: "CXC chemokines"
Visar resultat 1 - 5 av 20 avhandlingar innehållade orden CXC chemokines.
1. On CXC Chemokines in Endotoxin-Induced Liver Injury
Sammanfattning : Leukocyte recruitment is a rate-limiting step in endotoxemic liver injury. Leukocyte extravasation is a multistep process, supported by multiple combinations of adhesion molecules and chemokine receptors. This thesis examined the mechanisms of activation, adhesion and extravascular infiltration of leukocytes in endotoxin-induced liver injury. LÄS MER
2. On the role of mast cells in chemokine-induced leukocyte recruitment
Sammanfattning : Leukocyte recruitment is considered to playa key role in numerous inflammatory diseases. Tissue accumulation of Jeukocytes is a multi-steps process comprising rolling, adhesion and transmigration. LÄS MER
3. On Neutrophil and Platelet Adhesive Interactions in Septic Lung Injury
Sammanfattning : Sepsis induced by intestinal perforation is a life-threatening illness and is a frequent cause of leukocyte-mediated lung injury. Although antimicrobial therapy has been the central clinical strategy for these patients, the survival rates in such patients are still very low because of their impaired host defense mechanisms. LÄS MER
4. SIGNALING MECHANISMS IN SEPSIS-INDUCED IMMUNE DYSFUNCTION
Sammanfattning : Sepsis and subsequent organ failure remain the major cause of mortality in intensive care units in spite of significant research efforts. The lung is the most vulnerable organ affected by early hyper-inflammatory immune response in septic patients. LÄS MER
5. Mechanisms of neutrophil recruitment in septic lung injury
Sammanfattning : Sepsis is one of leading cause of death despite aggressive surgical intervention and antibiotic therapies. Excessive neutrophil recruitment is a major feature in early phase with immune system dysfunction at later phase. Lung is the most vulnerable, critical and sensitive organ during sepsis process. LÄS MER