Sökning: "CPP"

Visar resultat 31 - 35 av 66 avhandlingar innehållade ordet CPP.

1. 31. Cell-Penetrating Peptides for Mitochondrial Targeting

   Författare :Carmine Pasquale Cerrato; Ülo Langel; Shana O. Kelley; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial targeting; cell-penetrating peptides; antioxidant activity; scavenging ability; oligonucleotide delivery; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Mitochondria have simply been known as the cell’s powerhouse for a long time, with its vital function of producing ATP. However, substantially more attention was directed towards these organelles once they were recognized to perform several essential functions having an impact in cell biology, pharmaceutics and medicine. LÄS MER

3. 32. Cell-penetrating peptides, novel synthetic nucleic acids, and regulation of gene function : Reconnaissance for designing functional conjugates

   Författare :Peter Guterstam; Ülo Langel; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptide; nucleic acids; alternative splicing; mismatch discrimination; Neurochemistry; Neurokemi;

   Sammanfattning : Our genome operates by sending instructions, conveyed by mRNA, for the manufacture of proteins from chromosomal DNA in the nucleus of the cell to the protein synthesizing machinery in the cytoplasm. Alternative splicing is a natural process in which a single gene can encode multiple related proteins. LÄS MER

4. 33. Early Physiotherapy in the Neurointensive Care Unit - Passive Physiotherapy Interventions

   Författare :Annelie Thelandersson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiotherapy; Brain injury; Stroke; Intensive care unit; Prone position; Range of motion; Continuous passive motion; Intra cranial pressure; Cerebral perfuison pressure; Haemodynamics;

   Sammanfattning : Background: In critically ill patients, treated in the neurointensive care unit (NICU) because of severe brain injury or stroke, physical activities have been restricted to a minimum due to the potential risks of complications and adverse events. Nevertheless, passive physiotherapy treatments are widely used without conclusive evidence for their safety. LÄS MER

5. 34. Alzheimer Aβ peptides induce dysregulation of C/EBP and NF-кB in glial cells

   Författare :Malin Samuelsson; Kerstin Iverfeldt; Piet Eikelenboom; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-β; astrocytes; C EBP; glia; microglia; neuroinflammation; NF-кB; Neurochemistry; Neurokemi; Neurochemistry and Neurotoxicology; neurokemi och neurotoxikologi;

   Sammanfattning : Inflammation is believed to contribute to neurodegeneration in Alzheimer’s disease (AD). AD in turn is believed to be a consequence of accumulated amyloid-β (Aβ) peptides, that subsequently form senile plaques, due to imbalance between production and clearance of Aβ. LÄS MER

7. 35. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects

   Författare :Carmine Pasquale Cerrato; Ülo Langel; Lena Mäler; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptide; mitochondrial targeting; ROS reduction; mitochondrial membrane potential; antioxidant activity; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. LÄS MER