Sökning: "CPP"

Visar resultat 41 - 45 av 66 avhandlingar innehållade ordet CPP.

  1. 41. Enhancing the efficiency of viral and non-viral gene delivery vectors

    Författare :Safa Bazaz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gene therapy, which involves the introduction, alteration, or deletion of genetic material within cells to treat or prevent disease, holds great promise for addressing various genetic disorders and other medical conditions. However, several challenges remain in the field, particularly concerning nucleic acid delivery into target cells. LÄS MER

  3. 42. Appetite regulating neuropeptides in alcohol addiction : focus on melanin concentrating hormone and its mch1-receptor

    Författare :Camilla Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Current treatment options for alcohol use disorders are limited in number and have limited efficacy. It is therefore important to find new, more effective medications. LÄS MER

  4. 43. Cerebral Hemodynamics through Intracrnial Pressure

    Författare :Sima Shahsavari; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Intracranial dynamics; Baroreceptor reflex; Secondary brain injury; Traumatic brain injury; Collapsible tubes; Intracranial pressure; Cushing reflex; Pulse wave propagation; Cerebral autoregulation; Cerebral compliance; Mathematical modelling;

    Sammanfattning : Traumatic Brain Injury (TBI) continues to be a major problem worldwide. Today, intensive care of patients with TBI is mainly focused on preventing and treating secondary brain injuries. High pressure inside the intracranial cavity has been found to be an important feature of disturbed cerebral dynamics and secondary injuries. LÄS MER

  5. 44. Cell-penetrating peptides in protein mimicry and oligonucleotide delivery : Applications and mechanisms

    Författare :Henrik Johansson; Ülo Langel; Michael Gait; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; cell-penetrating peptide; PNA; splicing; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : The plasma membrane functions as a barrier, restricting entry of hydrophilic pharmaceutical agents. Cell-penetrating peptides (CPPs) are capable of transporting bioactive cargos into the cell and have consequently been extensively investigated for their mechanism of entry and capability to deliver various cargos spanning from peptides to plasmids. LÄS MER

  7. 45. Cell-penetrating peptides and bioactive cargoes : Strategies and mechanisms

    Författare :Kalle Kilk; Ülo Langel; Michael J. Gait; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; delivery; Peptide nucleic acid; Biochemistry; Biokemi;

    Sammanfattning : The cell membrane is an impermeable barrier for most macromolecules. Recently discovered cell-penetrating peptides (CPPs) have gained lot of attention because they can cross the membrane, and even more, carry cargoes with them. How CPPs enter cells is still not clear, while the delivery of different cargoes has been convincingly shown. LÄS MER