Sökning: "CNTF"
Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet CNTF.
6. Regulation of neurotrophic signaling molecules in motor neurons, primary sensory neurons and target tissues in senescence
Sammanfattning : A hallmark of senescence is sensorimotor impairment, characterized by gait disturbance, deficits in postural control, and muscle weakness. The object of this thesis work was to elucidate some of the molecular basis underlying these disturbances, mainly referring to the occurrence of characteristic changes in gene-expression pattern, especially, alterations in trophic signaling associated with the phenotypic changes seen in motoneurons as well as primary sensory neurons and target muscles during aging. LÄS MER
7. Studies into The Mechanisms of Neurodegeneration and Neuroprotection in Rd1 Mouse Retina
Sammanfattning : Retinitis Pigmentosa (RP) is a group of uncured retinal diseases with the world wide incidence of about 1/3500. In spite of the huge efforts in past years, the mechanisms underlying this type of hereditary blindness has not been elucidated and nor any effective treatment available. LÄS MER
8. Human neural precursor cells in spinal cord repair
Sammanfattning : Traumatic spinal cord injury (SCI) often results in substantial neural cell death, axonal degeneration and demyelination, accompanied by loss of sensory and motor functions. Cell therapy may have neuroprotective effects, substitute for lost neural cells, promote regeneration and enhance remyelination in the lesioned spinal cord. LÄS MER
9. Spinal motoneurons and molecules related to neurotrophic function after axon injury
Sammanfattning : The capacity of motoneurons to survive and regenerate new axons after injuries such as axotomy depends on a great variety of parameters. After sciatic nerve transection (SNT) in adult rats and to some extent after a ventral funiculus lesion (VFL), many cells survive and regeneration is highly prioritized. LÄS MER
10. Intracellular mechanisms in rd1 mouse retinal degeneration
Sammanfattning : Retinitis pigmentosa (RP) is an inherited disorder and the leading cause of visual impairment in the working age population. It is caused by a number of different genetic mutations, all of which cause the rod photoreceptors to degenerate. As the rods become few in numbers, the cones will also begin to die, resulting in total blindness. LÄS MER
