Sökning: "CNTF"

Visar resultat 11 - 15 av 16 avhandlingar innehållade ordet CNTF.

  1. 11. On age related changes in axons and glia of the central nervous system

    Författare :Susanna Kullberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aging; synaptic input; spinal cord; hippocampus; amino acid neurotransmitters; astrocyte; microglia; oligodendroglia; C bouton; cholinergic; monoaminergic; cytokine;

    Sammanfattning : A growing body of evidence shows that phenotypic changes including axon aberrations, rather than loss of neurons, account for behavioral impairments during aging. The present thesis was undertaken to investigate the occurrence of axon aberrations in relation to transmitter identity, glial reaction and sensorimotor disturbances. LÄS MER

  3. 12. Experimental Injury to the Visual System : Molecular Studies of the Retina

    Författare :Ulrika Lönngren; Finn Hallböök; Fredrik Ghosh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retina; injury; ischemia; gene expression; brimonidine; alpha-2-adrenergic agonist; neuroprotection; growth factors; apoptosis; Müller cells; Neuroscience; Neurovetenskap;

    Sammanfattning : Retinal ganglion cells play a crucial role in the relay of visual signals from the eye to the brain. This cell type is affected and eventually lost in the eye disease glaucoma, resulting in progressive and irreversible loss of vision. LÄS MER

  4. 13. Stem cell differentiation, plasticity and regenerative mechanisms in the cholinergic system : implications for Alzheimer’s disease

    Författare :Mats Nilbratt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer´s disease; amyloid precursor protein; cholinergic differentiation; human embryonic stem cells; neural precursor; nicotinic acetylcholine receptor; neurotrophic factor; radial glial cells; transplantation;

    Sammanfattning : Stem cells are immature cells with self-renewal capacity. They are able to differentiate into multiple lineages that may serve as a source of expandable cells for various applications. LÄS MER

  5. 14. In the right place and at the right time : cellular and functional neuroanatomy of endocannabinoids and neuropeptides

    Författare :Joanne Bakker; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A plethora of chemical signals, including endocannabinoids and neuropeptides, enable neuronal communication beyond the classical neurotransmitters. Many of these molecules are also expressed during (early) brain development, helping neurons to mature and neuronal circuits to take form. LÄS MER

  7. 15. Effects of dopamine and excitotoxicity in experimental models of Huntington's disease

    Författare :Åsa Petersén; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; excitotoxicity; dopamine; Huntington s disease; striatum; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the HD gene, that leads to dysfunction and death of striatal neurons. The pathogenetic mechanisms underlying HD are not known, but excitotoxicity and dopamine (DA) have been suggested to play a role. LÄS MER