Sökning: "demyelination."

Visar resultat 1 - 5 av 63 avhandlingar innehållade ordet demyelination..

1. 1. Cerebral white matter changes in patients with cognitive impairment - clinical and pathophysiological aspects

   Författare :Michael Jonsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; white matter changes; vascular factors; cognitive impairment; neuropsychiatric symptoms; cerebrospinal fluid biomarkers; demyelination; axonal degeneration;

   Sammanfattning : Cerebral white matter changes (WMC), detected with computed tomography (CT) or magnetic resonance imaging (MRI), represent a common condition in elderly people. However, the prognostic, symptomatological and biochemical constituents of WMC are only partially known. LÄS MER

3. 2. Regulation of neurotrophic signaling molecules in motor neurons, primary sensory neurons and target tissues in senescence

   Författare :Yu Ming; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Aging; dorsal root ganglion; spinal cord; muscle; neurotrophins; GFRalpha; Ret; FGF-2; gp 130; CNTF; LIF; IL-6; receptors; protein; mRNA; glia; axon dystrophy; demyelination.;

   Sammanfattning : A hallmark of senescence is sensorimotor impairment, characterized by gait disturbance, deficits in postural control, and muscle weakness. The object of this thesis work was to elucidate some of the molecular basis underlying these disturbances, mainly referring to the occurrence of characteristic changes in gene-expression pattern, especially, alterations in trophic signaling associated with the phenotypic changes seen in motoneurons as well as primary sensory neurons and target muscles during aging. LÄS MER

4. 3. Genetic regulation of, and autoimmunity in, myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and multiple sclerosis

   Författare :Erik Wallström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :multiple sclerosis; experimental autoimmune encephalomyelitis; myelin oligodendrocyte glycoprotein; autoimmunity; major histocompatibility complex;

   Sammanfattning : Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS) with inflammation and plaques of demyelination. This thesis examines the genetic and immunological requirements or rat experiment autoimmune encephalomyelitis (EAE), an animal model of MS, to display both inflammatory and demyelinated CNS lesions with chronic and/or relapsing-remitting disease courses. LÄS MER

5. 4. Deciphering and fine-tuning of myeloid cells in CNS demyelinating conditions

   Författare :Keying Zhu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Demyelination in the central nervous system (CNS) is a characteristic of various neurological disorders, such as multiple sclerosis (MS), neuromyelitis optica (NMO), subacute combined degeneration (SCD), tabes dorsalis (syphilitic myelopathy), and more. Although the causes vary, CNS demyelination is often associated with a significant buildup of inflammatory activated myeloid cells, mainly consisting of CNS resident microglia and infiltrating monocyte-derived macrophages. LÄS MER

7. 5. MRI quantification of multiple sclerosis pathology

   Författare :Russell Ouellette; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative disease and a common cause of neurologic disability. MS pathology is characterized by demyelination, neuroaxonal loss and atrophy. LÄS MER