Sökning: "Biokemi och klinisk kemi"

Visar resultat 11 - 15 av 16 avhandlingar innehållade orden Biokemi och klinisk kemi.

1. 11. Leukocytes and Coronary Artery Disease : Experimental and Clinical Studies

   Författare :Eva Lindmark; Peter Kierulf; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Tissue factor; monocytes; platelets; cytokines; endothelial cells; unstable coronary artery disease; coagulation; inflammation; biochemical markers; IL-6; risk stratification; Biokemi; Biochemistry; Biokemi; Clinical Chemistry; klinisk kemi;

   Sammanfattning : Tissue factor (TF) is the initiator of the coagulation cascade. Monocytes do not normally express TF, but can be induced to do so by certain stimuli. Aberrant TF expression is important in the thrombotic complications of bacterial sepsis, certain malignancies and coronary artery disease (CAD). LÄS MER

3. 12. Novel factors affecting clearance of triacylglycerol-rich lipoproteins from blood

   Författare :Stefan K Nilsson; Gunilla Olivecrona; Aivar Lookene; Ko Willems van Dijk; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipoprotein; triacylglycerol; apolipoprotein A-V; ANGPTL; Cardiovascular medicine; Kardiovaskulär medicin; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : Apolipoprotein (apo) A-V is the most recently discovered member of a protein family responsible for the structure and metabolic fate of plasma lipoproteins. While most of the apolipoproteins are well characterized with regard to structure, interactions and function, the role of apoA-V is not well understood. LÄS MER

4. 13. Biochemical and structural studies of proteins supporting the genome replication of enteroviruses and Giardia intestinalis

   Författare :Kasturika Shankar; Lars-Anders Carlson; Daniel Hurdiss; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Structural Biology; Membrane reconstitution; Infectious diseases; Virus; Protozoa; Infectious Diseases; infektionssjukdomar; medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : The Enterovirus genus of the Picornaviridae family includes non-enveloped, positive-sense single-stranded RNA (ssRNA) viruses. This genus of viruses causes many diseases such as poliomyelitis by poliovirus (PV), cardiomyopathy by coxsackievirus B3 (CVB3), common cold by rhinoviruses (RVs) and meningitis by Enterovirus 71 (EV 71). The 7. LÄS MER

5. 14. Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels

   Författare :Hanna Pettersson; Maria Norlin; Kjell Wikvall; Paolo Parini; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP27A1; CYP7B1; cytochrome P450; estrogen receptor; androgen receptor; cholesterol; sex hormone; hydroxylation; steroid metabolism; regulation of steroid levels; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

   Sammanfattning : The enzymes CYP27A1 and CYP7B1 are widely expressed in various human tissues and perform catalytic reactions in cholesterol homeostasis and endocrine signaling. We have investigated the metabolism of a synthetic oxysterol. LÄS MER

7. 15. Role of yeast DNA polymerase epsilon during DNA replication

   Författare :Isabelle Isoz; Erik Johansson; Juhani Syväoja; Umeå universitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; DNA polymerase epsilon; eukaryotic DNA replication; fidelity; leading strand; Dpb2; Biochemistry and clinical chemistry; Biokemi och klinisk kemi;

   Sammanfattning : Each cell division, the nuclear DNA must be replicated efficiently and with high accuracy to avoid mutations which can have an effect on cell function. There are three replicative DNA polymerases essential for the synthesis of DNA during replication in eukaryotic cells. LÄS MER