Sökning: "Farmaceutisk biokemi"

Visar resultat 1 - 5 av 35 avhandlingar innehållade orden Farmaceutisk biokemi.

  1. 1. Cytochrome P450 Enzymes in Bile Acid Biosynthesis and Fatty Acid Metabolism Studies on Members of the Porcine CYP4A and CYP8B Subfamilies

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Kerstin Lundell; Uppsala universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; cytochrome P450; bile acids; fatty acids; CYP4A; CYP8B; genome; porcine; hyocholic acid; Farmaceutisk biokemi; PHARMACY Pharmaceutical biochemistry; FARMACI Farmaceutisk biokemi; farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : The present investigation is devoted to studies on porcine members of the cytochrome P450 4A (CYP4A) and CYP8B1 subfamilies, which are involved in bile acid biosynthesis and fatty acid metabolism. Hyocholic acid is considered to fulfil the requirements for trihydroxy bile acids in the domestic pig (Sus scrofa) in the absence of cholic acid. LÄS MER

  2. 2. Expression of Genes Encoding for Drug Metabolism in the Small Intestine

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Monica Lindell; Uppsala universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; CYPs; UGTs; interindividual variation; small intestine; human; rat; artemisinin; CAR-receptor regulation; Farmaceutisk biokemi; PHARMACY Pharmaceutical biochemistry; FARMACI Farmaceutisk biokemi;

    Sammanfattning : This investigation focused on the mRNA expression of drug metabolising Cytochromes P-450 (CYP) and UDP-glucuronosyltransferases (UGT) and the transport protein P-glycoprotein (Pgp) in the small intestine of humans and rats.The mRNA expression of the investigated genes in the human small intestine (duodenum) varies between individuals giving each one of us personal profile. LÄS MER

  3. 3. The Multifunctional HnRNP A1 Protein in the Regulation of the Cyp2a5 Gene Connecting Transcriptional and Posttranscriptional Processes

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Tina Glisovic; Uppsala universitet.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biochemistry; Cyp2a5; DNA-protein interaction; gene regulation; hnRNP A1; nucleocytoplasmic shuttling; RNA-protein interaction; RNA stabilization; posttranscriptional; transcriptional; Farmaceutisk biokemi; PHARMACY Pharmaceutical biochemistry; FARMACI Farmaceutisk biokemi;

    Sammanfattning : The mouse xenobiotic-inducible Cyp2a5 gene is both transcriptionally and posttranscriptionally regulated. One of the most potent Cyp2a5 inducers, the hepatotoxin pyrazole, increases the CYP2A5 mRNA half-life. LÄS MER

  4. 4. Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation Special Focus on Vitamin D and Sex Hormones

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johan Lundqvist; Uppsala universitet.; [2011]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenal steroidogenesis; CYP7B1; vitamin D; calcitriol; enzymatic regulation; transcriptional regulation; CYP21A2; aromatase; sex hormone; estrogen; androgen; nuclear receptor; PHARMACY Pharmaceutical biochemistry; FARMACI Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. LÄS MER

  5. 5. Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Hanna Pettersson; Uppsala universitet.; [2009]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CYP27A1; CYP7B1; cytochrome P450; estrogen receptor; androgen receptor; cholesterol; sex hormone; hydroxylation; steroid metabolism; regulation of steroid levels; PHARMACY Pharmaceutical biochemistry; FARMACI Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : The enzymes CYP27A1 and CYP7B1 are widely expressed in various human tissues and perform catalytic reactions in cholesterol homeostasis and endocrine signaling. We have investigated the metabolism of a synthetic oxysterol. LÄS MER