Sökning: "lipoprotein"

Visar resultat 1 - 5 av 306 avhandlingar innehållade ordet lipoprotein.

1. 1. Lipoprotein lipase : mechanism for adaptation of activity to the nutritional state

   Författare :Gengshu Wu; Thomas Olivecrona; Gunilla Olivecrona; Peter Nisson-Ehle; Umeå universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; adipose tissue; heparin; extracellular; nutrition; turnover; actinomycin; Biokemi; Biochemistry; Biokemi; Biochemistry; biokemi;

   Sammanfattning : Lipoprotein lipase (LPL) is an enzyme to hydrolyze triglycerides in lipoproteins and thereby make the fatty acids available for cellular metabolic reactions. Short-term fasting down-regulates LPL activity in adipose tissue. This regulation is through post-translational mechanism. LÄS MER

3. 2. Lipoprotein(a) in cardiovascular disease

   Författare :Ulf Lundstam; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
   Nyckelord :atherosclerosis; Lipoprotein a ; LDL; extracellular matrix; women;

   Sammanfattning : The atherosclerotic process is continuous and starts early in life. Risk factors for atherosclerosis include hyperlipidemia, hypertension, smoking and diabetes mellitus. Fatty streaks characterised by lipid-laden macrophages are early signs of atherosclerosis. LÄS MER

4. 3. Regulation of Lipoprotein Lipase Activity : an In-vitro Study of a Complex and Dynamic System

   Författare :Oleg Kovrov; Gunilla Olivecrona; Aivar Lookene; Mikael Larsson; Geesje Dallinga-Thie; Umeå universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Triglyceride Metabolism; Lipoprotein lipase; Angiopoietin-Like Proteins; Apolipoproteins; Isothermal titration calorimetry; Biochemistry; biokemi; molekylärbiologi; Molecular Biology;

   Sammanfattning : The progress of human society outpaces our biological evolution, and this brings unexpected health problems. The industrial revolution brought up dramatic changes in nutrition and lifestyle – we are increasingly shifting towards a nutrient-rich Western-patterned diet and to a sedentary lifestyle. LÄS MER

5. 4. Lipoprotein lipase-unstable on purpose?

   Författare :Liyan Zhang; Gunilla Olivecrona; Cecilia Holm; Umeå universitet; []
   Nyckelord :Biochemistry; Lipoprotein lipase; Apolipoprotein CII; dimerization; monomerization; Molecular chaperones; Biokemi;

   Sammanfattning : Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. It is a non-covalent, homodimeric and N-glycosylated protein, which is regulated in a tissue-specific manner and is dependent on an activator protein, apolipoprotein CII. Dissociation of active LPL dimers to monomers leads to loss of activity. LÄS MER

7. 5. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

   Författare :Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

   Sammanfattning : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. LÄS MER