Sökning: "Biokemi och klinisk kemi"

Visar resultat 6 - 10 av 16 avhandlingar innehållade orden Biokemi och klinisk kemi.

1. 6. Prostasomes as Diagnostic, Prognostic and Therapeutic Vesicles

   Författare :Louise Dubois; Anders Larsson; Lucia Mincheva-Nilsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Exosomes; Prostasomes; Lipid rafts; Bioengineered vesicles; Prostate cancer; Purinergic receptors; Thymidine kinase 1; Medical Biochemistry; Medicinsk biokemi;

   Sammanfattning : This thesis explores prostasomes and their ability to be used as a new diagnostic tool for prostate cancer. Alongside diagnosis, this thesis also suggests prostasomes as a tool for prognosis and therapeutic treatment in patients with prostate cancer. LÄS MER

3. 7. Computational exploration of cancer genomes

   Författare :Joakim Karlsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cancer genomics; Transcriptomics; Driver genes; Copy number changes; Immunogenomics; Cancer of unknown primary; Uveal melanoma;

   Sammanfattning : Cancer evolves due to changes in DNA that give a cell an advantage at the expense of the remaining organism. These alterations range from individual base substitutions to broad losses or duplications of chromosomal material. LÄS MER

4. 8. Transcriptional profiling of human embryonic stem cells and their functional derivatives

   Författare :Jane Synnergren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; transcription; differentiation; human embryonic stem cells; gene expression; Naturvetenskap;

   Sammanfattning : Human embryonic stem cells (hESCs) represent populations of pluripotent, undifferentiated cells with unlimited replication capacity, and with the ability to differentiate into any functional cell type in the human body. Based on these properties, hESCs and their derivatives provide unique model systems for basic research on embryonic development. LÄS MER

5. 9. CarcinoEmbryonic Antigen-related Cell Adhesion Molecule 8 (CEACAM8) : Purification, Characterization, Cellular and Clinical Studies

   Författare :Linshu Zhao; Per Venge; Claes Dahlgren; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; human neutrophil; human eosinophil; granule proteins; CEA; CEACAM8; G-CSF; ELISA; subcellular fractionation; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : A 95-kDa protein was purified from normal human granulocytes. The protein reacted with a monoclonal antibody against CEACAM8. MALDI-Tof and MS/MS analyses revealed the protein to be a CGM6 gene product. Thus, the protein was proved to be identical to CEACAM8. LÄS MER

7. 10. NMR STUDIES ON STRUCTURE AND DYNAMICS OF TWO-DOMAIN PROTEINS

   Författare :Houman Ghasriani; Biofysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Fysikalisk kemi; Biochemistry; Metabolism; Biokemi; metabolism; Physical chemistry; Molekylär biofysik; CRISP-3; NMR; 3D-structure; NMR relaxation; Molecular biophysics; Prostate cancer; EGF module; PSP94; Beta-microseminoprotein; Protein S;

   Sammanfattning : The general objective of the present thesis work was to examine 3-dimensional structure as well as the motional properties of two different types of two-domain proteins by solution-state NMR. One of the major tasks of this thesis work was to investigate the domain orientation of these molecules by employing residual dipolar couplings (RDC) which can be used as orientational restraints for increasing the accuracy of protein structures determined by NMR. LÄS MER