Sökning: "5-HT2A receptor"

Visar resultat 1 - 5 av 28 avhandlingar innehållade orden 5-HT2A receptor.

1. 1. 5-HT2A : a serotonin receptor with a possible role in joint diseases

   Författare :Anders Kling; Solbritt Rantapää-Dahlqvist; Carl-Olav Stiller; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 5-HT2A serotonin receptor; serotonin; rheumatoid arthritis; adverse drug reaction; HTR2A; glucocorticoids; klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : BackgroundSerotonin (5-HT), an amino acid derivative and neurotransmitter, has for long been studied in relation to inflammation. It is an endogenous ligand for several different types of serotonin receptors. The serotonin receptor 5-HT2A has been reported to have a role in the pathophysiology of arthritis in animal experiment models. LÄS MER

3. 2. Serotonergic receptor subtypes in learning and memory : focus on 5-HT1A, 5-HT1B and 5-HT2A receptors

   Författare :Maria Lüttgen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Serotonin; 5-HT1A receptor; 5-HT1B receptor; 5-HT2A receptor; acetylcholine; NMDA receptor; water maze; passive avoidance; septum; hippocampus; teaming; memory; immunohistochemistry; mRNA;

   Sammanfattning : The aim of this thesis was to study how serotonin (5-HT) receptor subtypes can influence hippocampus/amygdala-dependent teaming and memory using the water maze (WM) and the passive avoidance (PA) tasks in rodents, and to provide a cellular correlate to the behavioral results using histochemical methods. Glutamatergic neurons in the trisynaptic circuit of the hippocampus are believed to be important for spatial teaming and memory as well as synaptic plasticity. LÄS MER

4. 3. Spinal Acetylcholine Release : Mechanisms and Receptor Involvement

   Författare :Mahinda Kommalage; Urban Höglund; Ernst Brodin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; acetylcholine release; spinal antinociception; nicotinic receptor; serotonin; GABA; Neurovetenskap; Neurology; Neurologi;

   Sammanfattning : Impulses coming from peripheries are modified in the spinal cord and transmitted to the brain. Several neurotransmitters have been involved in the processing of impulses in the spinal dorsal horn. Acetylcholine (ACh) is one of many neurotransmitters involved in the regulation of nociception in the spinal cord. LÄS MER

5. 4. Receptor Upregulation and MAPK Activity in Arteries and Bronchi Following Secondhand Smoke Exposure

   Författare :Lei Cao; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; coronary arteries; cerebral arteries; 5-hydroxytryptamine receptor; endothelin receptor; secondhand smoke exposure; bronchi;

   Sammanfattning : Cigarette smoking is a major risk factor for cardiovascular and respiratory diseases. Contractile receptor changes have been observed in several vascular diseases. The intracellular mitogen activated protein kinase (MAPK) signaling pathways are suggested to be associated with receptor upregulation. LÄS MER

7. 5. Clozapine as a dopamine D₁ receptor agonist

   Författare :Peter Salmi; Leif Lindström; Stockholms universitet; []
   Nyckelord :psykologi; Psychology;

   Sammanfattning : Objectives'. The present study had two major objectives; [1] to examine the specific role of dopamine D, and DM receptors in body temperature regulation in rats, and [2] to examine in vivo dopamine D, and Dm receptor agonist/antagonist properties of clozapine by use of core temperature measurements.Methods'. LÄS MER