Sökning: "vascular smooth muscle cell"

Visar resultat 31 - 35 av 132 avhandlingar innehållade orden vascular smooth muscle cell.

1. 31. Cell death in atherosclerosis

   Författare :Milita Crisby; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :atherosclerosis; carotid artery stenosis; ischemic stroke; apoptosis; necrosis; lipid peroxidation; plaque stability; pravastatin; inflammation; 27-[alpha]-hydroxylase;

   Sammanfattning : Rupture of atherosclerotic lesions is recognized as the major cause of acute cerebrovascular and coronary syndromes. The characteristics of the typical vulnerable plaque include increased inflammatory cells at the shoulder region, a large lipid core, a thin fibrous cap with few collagen fibers and smooth muscle cells. LÄS MER

3. 32. NFAT signaling in chronic and acute inflammation - A novel target for the treatment of diabetic vascular complications and acute pancreatitis?

   Författare :Anna Zetterqvist; Diabetiska komplikationer; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NFAT; vascular; diabetes; inflammation; atherosclerosis; diabetic retinopathy; acute pancreatitis; osteopontin; VCAM-1; A-285222;

   Sammanfattning : Diabetic patients suffer from macro- and microvascular complications causing increased morbidity and mortality. How hyperglycemia provokes vascular damage remains unclear, but glucose is believed to fuel a harmful low-grade chronic inflammation of the vessel wall. LÄS MER

4. 33. Effects of Biomechanical Stress on Gene Regulation in Vascular Cells

   Författare :Maria Carlström; Göteborgs universitet; []
   Nyckelord :shear stress; intraluminal pressure; endothelium; gene expression; DNA microarray; real-time RT-PCR; reference genes; smooth muscle cells; P2 receptors; TNF-alpha; urokinase-type plasminogen activator;

   Sammanfattning : The vascular vessel wall is constantly exposed to biomechanical forces, such as shear and tensile stress. Biomechanical forces are important for several physiological and pathological processes and have been shown to regulate a number of fundamental vascular functions, such as vascular tone and remodeling processes. LÄS MER

5. 34. Engineering the shape of bacterial cellulose and its use as blood vessel replacement

   Författare :Henrik Bäckdahl; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; tissue engineering.; smooth muscle cells; bacterial cellulose; scaffold design; tubular fermentation; biocompatibility evaluation; Blood vessel; vascular graft;

   Sammanfattning : Tissue loss and organ failure are major health problems that impose great costs on society. Cardiovascular diseases are responsible for 36% of mortalities and the disease burden among adults over the age of 60. The single largest cardiovascular disease is atherosclerosis in the coronary artery. LÄS MER

7. 35. Retinoids in the modulation of vascular inflammation

   Författare :Andreas Gidlöf; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Retinoids; metabolism; vascular smooth muscle cell; nitric oxide; inflammation; proliferation; restenosis;

   Sammanfattning : Vascular disease is multifactorial. Smooth muscle cells, the major constituent of the normal vessel wall, play a pivotal role. The pathogenesis includes cellular differentiation, proliferation and inflammatory activation. LÄS MER