Sökning: "necrosis"

Visar resultat 1 - 5 av 387 avhandlingar innehållade ordet necrosis.

  1. 1. Signal transduction pathways leading to apoptosis or necrosis in insulin-producing cells and prevention of cell death using gene transfer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johan Saldeen; Uppsala universitet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cells; apoptosis; Bcl-2; p38 mitogen activated kinase; NF-kB; necrosis; sphingomyelmase; ceramide; poly ADP-ribose polymerase; nitric oxide; IL-1β; TNF-a; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Signal transduction pathways potentially involved in destruction of insulin-producing β-cells in type-l diabetes and gene transfer to prevent β-cell death were studied in vitro. Adenovirus-polylysine/DNA complexes (AdpL) or polycationic liposomes mediated high reporter gene expression in dissociated primary human, fetal porcine, rat and mouse islet cells whereas gene transfer to intact islets was less efficient. LÄS MER

  2. 2. Aspects of pathological apoptosis in the immature brain after hypoxia-ischemia

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Ulrika Hallin; Göteborgs universitet.; Gothenburg University.; [2004]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neonatal; rat; brain; hypoxia-ischemia; necrosis; apoptosis; calpain; caspase; Bcl-2; Bax; mitochondria; calcineurin.;

    Sammanfattning : The cause of mechanisms underlying perinatal brain injury is not fully known, but it results in a wide variety of neurological impairments in the affected children. When injured, neurons of the newborn brain are prone to undergo programmed cell death, apoptosis, since this genetic program is normally activated in some cells during development of the nervous system, even in the perinatal period. LÄS MER

  3. 3. Magnetic Resonance Imaging in Legg-Calvé-Perthes Disease

    Detta är en avhandling från Department of Radiology, Lund University

    Författare :Peter Hochbergs; Lunds universitet.; Lund University.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical physics; Histology; Metaphysis; Synovitis; Necrosis; Osteotomy; Arthrography; Magnetic Resonance Imaging; Legg-Calvé-Perthes Disease; Pediatrics; Hip; medicinsk instrumentering; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology;

    Sammanfattning : The aims of this study were: to compare the cartilaginous outline of the femoral head obtained on arthrograms with those on MR images and to correlate it to the bony head outlines on conventional radiograps; to study early, postoperative cartilaginous and bony remodeling of the femoral head, after proximal femoral varus derotation extension osteotomy, with MR imaging and conventional radiography; to describe signal abnormalities on MR images in the femoral epiphysis, their location, extent and restitution over time; to evaluate the degree and persistence of synovitis in the hip joint by MR imaging; to analyze the metaphyseal histology and to correlate it to the signal intensity on the MR images in the corresponding biopsy region. Results and conclusions: MR imaging and arthrography define the shape of the femoral head cartilage equally well. LÄS MER

  4. 4. On ischemia/reperfusion injury and rejection in concordant xenotransplantation to the rat

    Detta är en avhandling från Department of Radiology, Lund University

    Författare :Daniel Jan Lukes; Göteborgs universitet.; Gothenburg University.; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Concordant; xenotransplantation; rat; hamster; mouse; rejection; necrosis; PCr; ß-ATP; ROS; SOE light; I RP; IPC;

    Sammanfattning : Studies in concordant (without preformed antibodies) rodent xenotransplantation (transplantation between species) models have focused, to date, on immunological disparities. In allotransplantation (transplantation within species), there is evidence suggesting that early ischemic events may contribute to later rejection episodes and to the development of chronicrejection features. LÄS MER

  5. 5. Mechanisms of Mitochondria-Induced Brain Damage Following Ischemia and Hypoglycemia

    Detta är en avhandling från Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, 221 85 Lund, Sweden

    Författare :Michel Ferrand-Drake; Lunds universitet.; Lund University.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; neuronal death; calpain; caspase; mitochondrial permeability transition; necrosis; apoptosis; cerebral ischemia; hypoglycemia; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Popular Abstract in Swedish Det finns en rad situationer då celler, företrädesvis nervceller, i hjärnan dör till följd av en kraftigt begränsad eller helt förhindrad blodtillförsel sk. ischemi. Till dessa hör "Stroke" eller slaganfall. LÄS MER