Sökning: "trypanosomiasis"

Visar resultat 11 - 15 av 16 avhandlingar innehållade ordet trypanosomiasis.

1. 11. On the Stereoselective Pharmacokinetics of Eflornithine and Prediction of Drug Tissue to Plasma Concentration Ratios

   Författare :Rasmus Jansson Löfmark; Göteborgs universitet; []
   Nyckelord :Human African trypanosomiasis; HAT; Pharmacokinetics; NONMEM; Stereoselectivity; Eflornithine; Tissue distribution;

   Sammanfattning : Eflornithine is one of two registered drugs for the treatment of late-stage human African trypanosomiasis, a uniformly fatal neglected disease with sixty million people are at risk of being infected. Eflornithine is efficacious but the cumbersome intravenous administration leaves numerous patients untreated. LÄS MER

3. 12. Development of analytical methods for determination of drugs, used against tropical diseases, in biological fluids

   Författare :Mikaela Malm; Högskolan Dalarna; []
   Nyckelord :;

   Sammanfattning : The overall aim of this thesis was to develop analytical methods for determination of drugs, used against tropical diseases, in biological fluids. For the treatment of malaria, piperaquine (PQ) is used in combination with another antimalarial. LÄS MER

4. 13. Towards time-resolved molecular interaction assays in living bacteria

   Författare :João Crispim Encarnação; Karl Andersson; Marika Nestor; U. Helena Danielson; Hélène Munier-Lehmann; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intracellular Molecular Interactions; Real-Time Cell Binding Assays; Bacteria; LigandTracer; Kinetics; Biokemi; Biochemistry; Biofarmaci; Biopharmaceutics; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Rare and neglected diseases such as multidrug resistant (MDR) tuberculosis, malaria and trypanosomiasis are re-emerging in Europe. New strategies are needed to accelerate drug discovery to fight these pathogens. LÄS MER

5. 14. Natural Products from Cameroonian Medicinal Plants

   Författare :Apollinaire Tsopmo; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Växtbiokemi; Plant biochemistry; antiplasmodial.; antitrypanosomal; diarylheptanoids; terpenoids; flavonoids; aframodial; Aframomum; Reneilmia cincinnata; Dorstenia; Euphorbia; Lepidobotrys staudtii; Pentadiplandra brazzeanea; Vernonia guineensis; Natural products; Myrica arborea;

   Sammanfattning : Natural product chemistry is a main research area in Cameroon, as well as for the division of Bioorganic Chemistry at Lund Institute of Technology. A review of the results obtained recently with Cameroonian medicinal plants shows that a large number of compounds, many with complex structures, have been isolated and characterised, and the work presented in this thesis is part of this effort. LÄS MER

7. 15. Circadian rhythm dysfunction in the suprachiasmatic nucleus : effects of Trypanosoma brucei brucei infection and inflammatory cytokines

   Författare :Gabriella B Lundkvist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Suprachiasmatic nucleus; slice; Trypanosoma brucei; sleeping sickness; spontaneous firing; rhytm; synaptic activity; GABA; glutamate; AMPA cytokines; sleep regulation; interferon-gamma; tumor necrosis factor-alpha;

   Sammanfattning : Alterations in the mammalian circadian pacemaker, the hypothalamic suprachiasmatic nuclei (SCN), were studied in an experimental rat model of African trypanosomiasis, or sleeping sickness, caused by infections with subspecies of Trypanosoma brucei (T b). Characteristic signs of the disease are marked disturbances in circadian rhythms, such as a fragmentation of the sleep-wake cycle. LÄS MER