Sökning: "spontaneous firing"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden spontaneous firing.

  1. 1. Cursed complexity. Computational properties of subcortical neuronal microcircuitry in sensorimotor control

    Författare :Anton Spanne; Hjärnans sensorimotoriska funktioner; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; spike firing statistics; spontaneous activity; sensorimotor control; tactile processing; cuneate nucleus; sparse coding; spinal border cells; cerebellum;

    Sammanfattning : One of the big obstacles for understanding the nervous system is its inherent complexity. It poses problems when interpreting both experimental and theoretical studies since we are currently forced to consider only reduced variants of the actual circuitry of the brain. LÄS MER

  3. 2. Circadian rhythm dysfunction in the suprachiasmatic nucleus : effects of Trypanosoma brucei brucei infection and inflammatory cytokines

    Författare :Gabriella B Lundkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Suprachiasmatic nucleus; slice; Trypanosoma brucei; sleeping sickness; spontaneous firing; rhytm; synaptic activity; GABA; glutamate; AMPA cytokines; sleep regulation; interferon-gamma; tumor necrosis factor-alpha;

    Sammanfattning : Alterations in the mammalian circadian pacemaker, the hypothalamic suprachiasmatic nuclei (SCN), were studied in an experimental rat model of African trypanosomiasis, or sleeping sickness, caused by infections with subspecies of Trypanosoma brucei (T b). Characteristic signs of the disease are marked disturbances in circadian rhythms, such as a fragmentation of the sleep-wake cycle. LÄS MER

  4. 3. Effects of aging and inflammatory molecules on the suprachiasmatic circadian clock

    Författare :Mikael Nygård; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Circadian; suprachiasmatic; synaptic; inflammation; cytokine; SOCS; interferon; tumor necrosis factor; neuron; firing;

    Sammanfattning : The suprachiasmatic nucleus (SCN) is considered the master circadian pacemaker in the mammalian brain and is vital for generating physiological and behavioral circadian rhythms. During aging and inflammatory conditions the circadian system is frequently affected, but relatively little is known about the mechanisms underlying such effects. LÄS MER

  5. 4. Role of potassium channels in regulating neuronal activity

    Författare :Göran Klement; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Potassium channels; threshold dynamics; trafficking; hERG; SMOCs; excitability;

    Sammanfattning : The firing behaviour of excitable cells is fundamental for the information processing in multicellular organisms, varying from single spikes to different forms of repetitive firing. Of the many regulators, voltage gated potassium channels play a major role. In this thesis some aspects of the potassium channel regulation of firing are explored. LÄS MER

  7. 5. The role of striatal inhibition in the processing of cortical neuronal avalanches

    Författare :Andreas Klaus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The brain is spontaneously active even in the absence of any obvious motor actions or sensory perceptions. This so-called resting activity or ongoing activity reflects the myriads of neuronal interactions necessary for the brain to process past actions, allow for current inputs, and prepare for future decisions and responses. LÄS MER