Sökning: "synaptic activity"

Visar resultat 1 - 5 av 158 avhandlingar innehållade orden synaptic activity.

  1. 1. Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides

    Författare :Andreas Toft Sörensen; Experimentell Epilepsi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LTP; synaptic plasticity; synaptic transmission; electrophysiology; Y5 receptor; Y2 receptor; neuropeptide Y NPY ; hippocampus; gene therapy; epilepsy; memory; activity-dependent release; volume transmission;

    Sammanfattning : Intractable seizures and lack of effective antiepileptic drugs (AED) are severe and common conditions affecting many patients with epilepsy. Thus, there is an urgent need to develop new therapies in epilepsy. The search for novel treatments has identified several neuropeptide systems as potential targets for future therapeutic interventions. LÄS MER

  3. 2. Role of Endogenous BDNF and NT3 for Synaptic Transmission and Plasticity in the Dentate gyrus

    Författare :Klara Olofsdotter; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hippocampus; dentate gyrus; GABA; glutamate; synaptic transmission; synaptic plasticity; Brain-derived neurotrophic factor; neurotrophin 3; Neurologi; neurophysiology; neuropsychology; Neurology; electrophysiology; neurofysiologi; neuropsykologi;

    Sammanfattning : The neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. LÄS MER

  4. 3. Activity-dependent changes of synaptic transmission in a long-term perspective and processes involved

    Författare :Mikhail Dozmorov; Göteborgs universitet; []
    Nyckelord :synaptic plasticity; hippocampus; LTP; LTD; AMPA; NMDA; protein synthesis;

    Sammanfattning : Synaptic plasticity is an essential property of the central nervous system. It is thought torepresent a mechanism for memory aquisition, storage and recall. The most well studied forms ofsynaptic plasticity are homosynaptic NMDAR-dependent LTP and LTD in the hippocampus inducedby specific patterns of electrical stimulation. LÄS MER

  5. 4. Synaptic transmission and synaptic plasticity in the mouse striatum

    Författare :Sietske Schotanus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The striatum is the major input nucleus of the basal ganglia and can be subdivided into a dorsal part and a ventral part that is also named nucleus accumbens (NAc). The dorsal part is involved in motor control and habit learning whereas the ventral part is mostly associated with rewardmotivated behaviors. LÄS MER

  7. 5. Beyond AMPA and NMDA: Slow synaptic mGlu/TRPC currents : Implications for dendritic integration

    Författare :Marcus Petersson; Erik Fransén; Abdel El Manira; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transient receptor potential; TRP; metabotropic glutamate receptor; mGlu1 5; dendritic integration; synaptic activation; temporal summation; low-frequency; entorhinal cortex; mathematical model; computational neuroscience; Computer science; Datavetenskap;

    Sammanfattning : In order to understand how the brain functions, under normal as well as pathological conditions, it is important to study the mechanisms underlying information integration. Depending on the nature of an input arriving at a synapse, different strategies may be used by the neuron to integrate and respond to the input. LÄS MER