Sökning: "tumor necrosis factor-alpha"
Visar resultat 1 - 5 av 63 avhandlingar innehållade orden tumor necrosis factor-alpha.
1. Tumor Necrosis Factor-alpha as a target cytokine in vascular disease
Sammanfattning : Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). LÄS MER
2. Oxygen delivery and mitochondrial dysfunction as assessed by microdialysis during interventions in experimental sepsis
Sammanfattning : Early administration of broad-spectrum antibiotics is the first goal in sepsis treatment. Besides from bacteriostatic/bactericidal effects, some antibiotics may also modify the host´s response to infection. The novel antibiotic tigecycline may exert such properties; however, this property has not been evaluated in large-animal trials. LÄS MER
3. Studies of the pathogenesis of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura
Sammanfattning : This study investigated the pathogenesis of hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). (1) The relative roles of lipopolysaccharide and Shiga-like toxin-2 were studied in a mouse model of Escherichia coli O157:H7 infection. LÄS MER
4. Pain and radiographic changes of the arthritic temporomandibular joint : relation to cytokines in synovial fluid and plasma
Sammanfattning : In patients with rheumatoid arthritis and other inflammatory joint diseases, radiographic changes of the TMJ are frequently observed. Common symptoms of TMJ involvement are pain at rest and on movement of the jaw. LÄS MER
5. Regulation of prostaglandin E2 synthesis in human gingival fibroblasts
Sammanfattning : Prostaglandins, especially, prostaglandin E2 (PGE2) play an important role in inflammatory diseases such as rheumatoid arthritis and periodontitis. The aim of the present thesis was to study the production and the regulation of PGE2 with special reference to the key enzymes phospholipase A2 (PLA2) and cyclooxygenase (COX) at the rnRNA level in human gingival fibroblasts. LÄS MER