Sökning: "tissue oxygen tension"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden tissue oxygen tension.

1. 1. Tissue Perfusion and Oxygenation Evaluated by Measurements of Tissue Gases and pH. An Experiemental Study

   Författare :Åke Mellström; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intensive care; Anestesiologi; intensivvård; Anaesthesiology; Tissue pH; Tissue PCO2; Oxygen utilization; Tissue PO2;

   Sammanfattning : Optimum peripheral perfusion, oxygenation and oxygen utilization is a prerequisite for normal wound healing, resistance to infection and cardiac function. The purpose of this study was to evaluate peripheral oxygen utilization by measurements of subcutaneous tissue gases and pH (PscO2, PscCO2 and pHsc) in comparison to established techniques for measurements of periph-eral tissue oxygenation and oxygen utilization in experimental animal models with hyperoxia-hypoxia, acidosis-alkalosis and haemorrhage-resuscitation. LÄS MER

3. 2. Intrarenal oxygen homeostasis in acute and chronic kidney disease

   Författare :Oskar Nensén; Fredrik Palm; Börje Haraldsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; acute kidney injury; oxygen; kidney disease; renal physiology; Fysiologi; Physiology;

   Sammanfattning : Renal hypoxia has been recognized as a common feature of acute and chronic kidney injury arising from varying etiologies. It has also been proposed to provide a driving mechanism for the transition from acute to chronic kidney disease (CKD). LÄS MER

4. 3. The Role of Kidney Oxygen Homeostasis for the Development of Kidney Disease

   Författare :Carla Carvalho; Fredrik Palm; Peter Hansell; Malou Friederich; Jenny Nyström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oxygen; Kidney mitochondria; Hypoxia-inducible factors; Prolyl hydroxylase; von Hippel-Lindau; Diabetes; Aging; Kidney; Sodium; RAAS; Fysiologi; Physiology;

   Sammanfattning : The relation between oxygen supply and demand determines tissue oxygen tension (PO2). When intrarenal tissue PO2 decreases, any compensatory increase in oxygen supply via increased renal blood flow is likely to increase glomerular filtration rate. LÄS MER

5. 4. The Role of Mitochondrial Uncoupling in the Development of Diabetic Nephropathy

   Författare :Malou Friederich Persson; Fredrik Palm; Richard K. Porter; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kidney; mitochondria; Uncoupling Protein-2; Adenosine Nucleotide Transporter; uncoupling; diabetes; diabetic nephropathy; db db; dinitrophenol; Coenzyme Q10; oxygen; rats; mice; Physiology; Fysiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Diabetes is closely associated with increased oxidative stress, especially originating from the mitochondria. A mechanism to reduce increased mitochondria superoxide production is to reduce the mitochondria membrane potential by releasing protons across the mitochondria membrane. LÄS MER

7. 5. Aspects of Regulation of GFR and Tubular Function in the Diabetic Kidney : Roles of Adenosine, Nitric Oxide and Oxidative Stress

   Författare :Patrik Persson; Fredrik Palm; Peter Hansell; Bengt Rippe; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetes; diabetic nephropathy; glomerular filtration rate; renal blood flow; insulin; renal hemodynamics; micropuncture; oxygen; NADPH-oxidase; apocynin; streptozotocin; l-arginine; CGS21680; rats; mice; Physiology; Fysiologi; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Diabetic nephropathy is the main cause for initiation of renal replacement therapy and early symptoms in patients include increased glomerular filtration rate (GFR), decreased oxygen tension and albuminuria, followed by a progressive decline in GFR and loss of kidney function. Experimental models of diabetes display increased GFR, decreased tissue oxygenation and nitric oxide bioavailability. LÄS MER