Sökning: "Prolyl hydroxylase"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Prolyl hydroxylase.
1. The Role of Kidney Oxygen Homeostasis for the Development of Kidney Disease
Sammanfattning : The relation between oxygen supply and demand determines tissue oxygen tension (PO2). When intrarenal tissue PO2 decreases, any compensatory increase in oxygen supply via increased renal blood flow is likely to increase glomerular filtration rate. LÄS MER
2. Analysis of HIF-1alpha degradation and function
Sammanfattning : HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic conditions, HIF-1alpha is rapidly degraded by the ubiquitinproteasome pathway. LÄS MER
3. Investigation of potential prognostic and therapeutic genes in pathologic neovascularization of the retina
Sammanfattning : Pathologic angiogenesis of the retina is a hallmark of frequent blinding conditions among the elderly, such as proliferative diabetic retinopathy (PDR) and neovascular age-related macular degeneration (nAMD). The underlying mechanisms are complex. LÄS MER
4. Skeletal muscle HIF-1 and exercise
Sammanfattning : Regular physical activity prevents and improves a number of disease conditions and reduces the risk for premature death substantially. From a clinical as well as a basic science point of view it is important to create a more fundamental understanding of the molecular mechanisms that contribute to the improved functional capacity induced by regular physical activity. LÄS MER
5. Interactions between the stroma and thyroid epithelial cells of normal and malignant origin
Sammanfattning : Endocrine and locally produced factors as well as interactions between epithelial cells and the stroma important in the control of growth and function of the thyroid gland. In this study, the effects of, and mechanism(s) for, such cross-talk under some normal and pathological conditions were investigated. LÄS MER