Sökning: "sphingomyelinase"

Visar resultat 1 - 5 av 15 avhandlingar innehållade ordet sphingomyelinase.

1. 1. Alkaline Sphingomyelinase; A Potential Inhibitor in Colorectal Carcinogenesis

   Författare :Erik Hertervig; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Cytologi; cancerology; oncology; Cytology; Gastroenterologi; Gastro-enterology; HT-29; MIN mouse; FAP; colorectal cancer; human; alkaline sphingomyelinase;

   Sammanfattning : Sphingomyelin (SM) is present both in eucaryotic cells and the diet. Sphingomyelinase (SMase) hydrolyses SM and generates ceramide that has been implicated in the regulation of cell growth, differentiation and apoptosis. Previously a SMase with alkaline pH optimum was identified in the intestinal tract. LÄS MER

3. 2. Digestion and Absorption of Sphingomyelin from Milk

   Författare :Lena Nyberg; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastro-enterology; intestine; sphingolipid; ceramidase; sphingomyelinase; ceramide; Gastroenterologi;

   Sammanfattning : Sphingomyelin (SM) is a major component of mammalian cell membranes. Due to its widespread occurrence it is a dietary component, occurring mainly in milk, eggs, meat and fish. In the cell membrane SM was earlier considered to be only a structural element, which interacts with cholesterol and forms a system for bilayer stabilization. LÄS MER

4. 3. Inducible nitric oxide synthase in experimental urinary tract infection

   Författare :Mirjana Poljakovic; Avdelningen för klinisk kemi och farmakologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urology; host defense; cell viability; nitrate; lipopolysaccaride; cytokines; sphingomyelinase; mitogen activator protein kinase; nitric oxide; nitrotyrosine; E. coli; cyclooxygenase; urinary tract infection; prostaglandins; urothelium; bladder; kidney; NADPH diaphorase histochemistry; nitric oxide synthase; vävnadskultur; histokemi; cytokemi; Histologi; tissue culture; histochemistry; cytochemistry; Histology; nefrologi; Urologi; nephrology; Infections; Infektioner;

   Sammanfattning : Urinary tract infection (UTI) is among the most common bacterial infections in humans and the majority are caused by Escherichia coli (E. coli). Abundant evidence indicates that nitric oxide (NO) produced by the inducible NO synthase (iNOS) plays an important role in host defense against infection. LÄS MER

5. 4. Intestinal immune cells in health and disease. Dissecting histological characteristics of inflammatory bowel disease and inflamed lung using quantitative immunohistochemical image analysis

   Författare :Manar Alyamani; Adaptivt immunförsvar; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IBD; CD; UC; Quantitative imaging; COVID -19; NPP7 Nucleotide phosphodiesterase pyrophosphatase 7; alkaline sphingomyelinase; histopathology; Multiplexed IHC; Immunohistochemical staining; S1P Sphingosine-1-phosphate;

   Sammanfattning : .... LÄS MER

7. 5. Experimental Studies of Ursolic Acid and Alkaline Sphingomyelinase in Colon Cancer and Colitis

   Författare :David Andersson; Lund Medicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Sphingomyelin (SM) is a sphingolipid present in all eukaryotic cell membranes. Hydrolysis of SM by sphingomyelinase (SMase) generates ceramide, which has effects on cell-cycle regulation and apoptosis. LÄS MER