Sökning: "ceramide"

Visar resultat 1 - 5 av 35 avhandlingar innehållade ordet ceramide.

  1. 1. Localisation of Protein Kinase C in Apoptosis and Neurite Outgrowth

    Detta är en avhandling från Division of Molecular Medicine, Department of Laboratory Medicine, UMAS, Malmö

    Författare :Anna Schultz; Lund University.; Lunds universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Medicine human and vertebrates ; Medicin människa och djur ; Cytology; oncology; cancerology; Cytologi; Prostate Cancer; Neuroblastoma; Ceramide; Golgi Apparatus; Neurite outgrowth; Apoptosis; Protein Kinase C; C1 domain;

    Sammanfattning : Protein kinase C (PKC) is a family of serine/threonine kinases, which are subgrouped into classical (a, bI, bII, g), novel (d, e, h, q) and atypical (z, i/l) isoforms. One major aim of this thesis work was to investigate if altered levels of PKC isoforms influence the apoptotic responses of malignant cell-lines. LÄS MER

  2. 2. Signal transduction pathways leading to apoptosis or necrosis in insulin-producing cells and prevention of cell death using gene transfer

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Johan Saldeen; Uppsala universitet.; [1998]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; β-cells; apoptosis; Bcl-2; p38 mitogen activated kinase; NF-kB; necrosis; sphingomyelmase; ceramide; poly ADP-ribose polymerase; nitric oxide; IL-1β; TNF-a; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Signal transduction pathways potentially involved in destruction of insulin-producing β-cells in type-l diabetes and gene transfer to prevent β-cell death were studied in vitro. Adenovirus-polylysine/DNA complexes (AdpL) or polycationic liposomes mediated high reporter gene expression in dissociated primary human, fetal porcine, rat and mouse islet cells whereas gene transfer to intact islets was less efficient. LÄS MER

  3. 3. Glucose- and hypoxia-regulated insulin gene expression

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Linda Tillmar; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islet; beta-cell; insulin; mRNA stability; PTB; glucose; hypoxia; mTOR; p70s6k; ceramide; redox; ROS; Cellbiologi; MEDICINE Morphology; cell biology; pathology Cell biology; MEDICIN Morfologi; cellbiologi; patologi Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Although extensively studied, there are still many unanswered questions regarding the exact regulation of insulin gene expression. This is important to further investigate since it will hopefully help us understand the pathophysiology of some types of diabetes. LÄS MER

  4. 4. Skin hydration - How water and osmolytes influence biophysical properties of stratum corneum

    Detta är en avhandling från Department of Chemistry, Lund University

    Författare :Sebastian Björklund; Lund University.; Lunds universitet.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stratum corneum; diffusive transport; permeability; flow-through cell; Franz cell; transdermal drug delivery; water activity; vapor pressure; osmotic gradient; relative humidity; ceramide; free fatty acid; cholesterol; keratin filaments; natural moisturizing factor NMF ; urea; glycerol; molecular mobility; 13C natural-abundance solid-state NMR; polarization transfer; isothermal calorimetry; impedance spectroscopy; X-ray diffraction;

    Sammanfattning : The outermost layer of skin (i.e., the stratum corneum, SC) is the interface that separates the water-rich inside of the body from the relatively dry external environment. SC forms an effective permeability barrier, which has to be overcome in transdermal drug delivery. LÄS MER

  5. 5. Mechanisms of P fimbriae cell activation

    Detta är en avhandling från Department of Chemistry, Lund University

    Författare :Maria Hedlund; Lund University.; Lunds universitet.; [2000]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 1 fimbriae; LPS; glycosphingolipids; ceramide; E. coli; P fimbriae; mucosa; cytokines; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Microbial attachment to host cells plays a central role in the induction of inflammatory responses and the production of the disease. Uropathogenic Gram negative bacteria carry surface lectins that specifically recognize oligosaccharide receptor epitopes expressed on glycolipids or glycoproteins. LÄS MER