Sökning: "spheroids"

Visar resultat 21 - 25 av 55 avhandlingar innehållade ordet spheroids.

  1. 21. Novel in vitro systems elucidating metabolic health and disease

    Författare :Joanne X. Shen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The convoluted nature of biology warrants improved models that further insights into health and disease. Bioengineered features and platforms allow the modulation and study of a range of biological phenomena. LÄS MER

  3. 22. Proteomics informed investigation of human hepatocytes and liver tissue

    Författare :Niklas Handin; Per Artursson; Peter Nygren; Tobias Sjöblom; Mårten Fryknäs; Pieter Annaert; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; liver; hepatocytes; proteomics; cellular stress; apoptosis; hepatotoxicity; 3D culture; spheroid; drug metabolism; drug toxicity; drug transport; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : A successful drug needs to display beneficial absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) profile. It is therefore important to investigate these properties during the drug discovery process. LÄS MER

  4. 23. Different approaches to develop radio- and chemotherapy for treatment of human cancer

    Författare :Chitralekha Mohanty; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite huge advancements in our knowledge and understanding of the molecular mechanisms of carcinogenesis, the prognoses of many malignant diseases have not improved dramatically. Improvements in the therapeutic efficacy of several anti-cancer therapies including radiotherapy and chemotherapy would be required to achieve effective treatment. LÄS MER

  5. 24. Mechanistic analyses of hepatocyte plasticity

    Författare :Nuria Oliva-Vilarnau; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Adult hepatocytes are highly plastic cells which have a molecular toolbox for efficient regeneration. Yet, end stage liver diseases are becoming an increasing clinical burden. LÄS MER

  7. 25. Urinary bladder carcinoma, preclinical and clinical studies on EGFR based targeting

    Författare :Peter Bue; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; urinary bladder carcinoma; epidermal growth factor-dextran; radionuclide therapy; Kirurgi; Surgery; Kirurgi; kirurgi; särskilt urologi; Urology;

    Sammanfattning : Radical cystectomy with bilateral pelvic lymphadenectomy is the standard treatment for muscle-invasive transitional cell carcinoma of the urinary bladder. Despite presumably localised malignancies and efficacious management about 50% of patients will die within 5 years, the majority due to metastatic disease. LÄS MER