Sökning: "chemotherapy resistance"
Visar resultat 1 - 5 av 150 avhandlingar innehållade orden chemotherapy resistance.
1. Chemotherapy in Childhood Acute Lymphoblastic Leukemia : In vitro cellular drug resistance and pharmacokinetics
Sammanfattning : The aims of the studies described in this thesis were to investigate the pharmacokinetics of and cellular resistance to chemotherapy as causes of treatment failure in childhood acute lymphoblastic leukemia (ALL).Leukemic cells from 370 children with newly diagnosed ALL were tested by the Fluorometric Microculture Cytotoxicity Assay to measure their resistance to each of ten standard cytotoxic drugs. LÄS MER
2. Cancer Evolution under Chemotherapy Treatment
Sammanfattning : Background: Chemotherapy resistance is a critical issue in oncology, being responsible for the majority of deaths in modern cancer care. My PhD work has focused on two cancer types where such drug resistance is a major clinical issue: epithelial ovarian cancer (EOC) and Wilms tumor (WT). LÄS MER
3. ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells
Sammanfattning : Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. LÄS MER
4. Prognostic and treatment predictive factors for radio- and chemotherapy resistance in breast cancer patients- a step towards personlized medicine
Sammanfattning : Breast cancer is the most common cancer form among women in the Western world. Although treatment has improved during the last decades, there is still a significant proportion of the patients who are not cured. LÄS MER
5. Characterization of genetic alterations in ovarian cancer associated with chemotherapy response
Sammanfattning : Ovarian cancer is the most lethal of all gynecological malignancies, and exhibit an overall fiveyear survival rate of only 48% in Sweden. The high mortality in ovarian cancer is largely due to late diagnosis and chemotherapy resistance. LÄS MER