Sökning: "VLX50"

Hittade 1 avhandling innehållade ordet VLX50.

  1. 1. New preclinical strategies for characterization and development of anticancer drugs

    Författare :Henning Karlsson; Peter Nygren; Rolf Larsson; Mattias Belting; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; spheroids; green fluorescent protein; VLX50; VLX60; VLX600; nitazoxanide; radiation; radiosensitizer; Oncology; Onkologi;

    Sammanfattning : Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. LÄS MER