Sökning: "spheroids"
Visar resultat 16 - 20 av 55 avhandlingar innehållade ordet spheroids.
16. Tumour models in vitro : penetration of therapeutical agents and amiloride-induced growth disturbances in human glioma and colon carcinoma spheroids
Sammanfattning : .... LÄS MER
17. Development of therapeutic strategies for quiescent tumor cell populations
Sammanfattning : Phenotypic screening is an effective approach to the discovery of small-molecule drugs. In this thesis, I have used cancer cells grown as 3D microtissues (multicellular spheroids) to study the effect of anticancer drugs and as drug discovery tools. LÄS MER
18. Using a 3-d model system to screen for drugs effective on solid tumors
Sammanfattning : There is a large medical need for the development of effective anticancer agents with minimal side effects. The present thesis represents an attempt to identify potent drugs for treatment of solid tumors. LÄS MER
19. Towards personalized immunotherapy : development of in vitro models for imaging natural killer cell behavior in the tumor microenvironment
Sammanfattning : Tremendous advances in the tumor immunology field have transformed immunotherapy from a promising approach to a standard clinical practice. However, a subset of cancer patients is non-responsive to immunotherapy. More research is therefore needed to understand the mechanisms underlying tumor resistance to immunotherapeutic treatments. LÄS MER
20. Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation
Sammanfattning : Rapid advancement in the field of immunotherapy has changed the treatment landscape of cancer, especially with the approval of immune checkpoint inhibitors for a wide range of cancer types. However, a large proportion of patients does not benefit from this treatment. LÄS MER