Sökning: "radiosensitizer"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet radiosensitizer.

1. 1. New preclinical strategies for characterization and development of anticancer drugs

   Författare :Henning Karlsson; Peter Nygren; Rolf Larsson; Mattias Belting; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; spheroids; green fluorescent protein; VLX50; VLX60; VLX600; nitazoxanide; radiation; radiosensitizer; Oncology; Onkologi;

   Sammanfattning : Increased understanding of the molecular mechanisms underlying cancer development has shifted drug discovery towards target driven drug development the last decades, but the development of effective cancer drugs has been hampered by the lack of predictive preclinical models. 3-D cultures, considered to more accurately reflect solid tumors in vivo, have been proposed as one way to increase the predictability of clinical efficacy in cancer drug discovery and development. LÄS MER

3. 2. Förbättrad radionuklidterapi av neuroblastom

   Författare :Arman Romiani; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radionuclide therapy; Neuroblastoma; Somatostatin analog; 177Lu-octreotate; 177Lu-octreotide; Lorlatinib; Combination therapy; Radiosensitizer;

   Sammanfattning : Today, about half of the children diagnosed with high-risk neuroblastoma (HR-NB) survive due to considerable treatment improvements during the last decades. However, there is still much to be done for the other half who are not cured with current treatments. LÄS MER

4. 3. Repair of DNA double-stranded breaks in human cells

   Författare :Susanne Nyström; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA-PK; DNA double-stranded break; DSB; DNA single-stranded break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin gamma1; bleomycin; etoposide; topoisomerase II; radiotherapy; radiosensitizer; ATM;

   Sammanfattning : DNA is continuously subjected to degradation. Therefore, our cells need to constantly repair its DNA to prevent mutations and in the long run cancer. In mammalian cells, when DNA is broken right off, a double-stranded break (DSB) is produced, and the ends are ligated by a process called non-homologous end-joining (NHEJ). LÄS MER

5. 4. Recognition and signaling of DNA double-strand breaks in human cells

   Författare :Ismail Hassan Ismail; Göteborgs universitet; []
   Nyckelord :DNA-PK; DNA double-strand break; DSB; DNA single-strand break; SSB; DNA damage; ionizing radiation; IR; DNA repair; calicheamicin kappa1; ATM; hydrogen peroxide; H2AX; radiotherapy; radiosensitizer; flow cytometry;

   Sammanfattning : DNA double-strand breaks (DSBs) are the most toxic type of DNA damage. Fortunately, our cells have highly conserved pathways that detect and repair DSBs. Defects in DSB signaling and DSB repair pathways result in genomic instability that predisposes for cancer development. LÄS MER

7. 5. Searching for Synergy : Radiosensitization of 177Lu-DOTATATE

   Författare :Sara Lundsten; Marika Nestor; Hanna Björkelund; Katarina Edwards; Julie Nonnekens; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; targeted radionuclide therapy; radiosensitization; p53; MDM2 MDM4 inhibition; HSP90; drug synergy; drug delivery; lipid nanoparticles; lipodisks; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

   Sammanfattning : Cancers presents a major health challenge, and there is a pressing need to develop new therapeutic strategies. Surgery, chemotherapy and radiation are the most commonly used treatments for cancer today. Radiation can be given as targeted radionuclide therapy (TRT), i.e. LÄS MER