Sökning: "roles and functions of people"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden roles and functions of people.

  1. 1. Identification and Functional Significance of Aberrant Long Non-coding RNAs in Acute Myeloid Leukemia : Biological and Prognostic Implications

    Författare :Anne H. Neddermeyer; Sören Lehmann; Jonas Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acute myeloid leukemia AML ; hematopoiesis; long non-coding RNAs lncRNAs ; RNA- and CAGE-sequencing; CRISPRi; CRISPR-Cas9; NEAT1; APL; NPM1; IDH2; all-trans retinoic acid; arsenic trioxide; venetoclax; drug resistance and sensitivity; prognosis; RADICL-sequencing; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Acute myeloid leukemia (AML) is the most frequently diagnosed type of acute leukemia in adults. It commonly affects people aged 60 or older, as incidence increases with age, and it is characterized by the accumulation of immature hematopoietic progenitor cells in the bone marrow. LÄS MER

  3. 2. Immunosuppressive and metastasis-promoting matrisome proteins in pancreatic cancer : the role of galectin 4 and SERPINB5

    Författare :Tommy Lidström; Daniel Öhlund; Håkan Hedman; Ola Billing; Andreas Lundqvist; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic cancer; galectin 4; immunotherapy; SERPINB5; metastasis; extracellular matrix; drug target; Oncology; onkologi; immunologi; Immunology; Medicine; medicin;

    Sammanfattning : In Sweden 1200-1300 people are diagnosed with pancreatic ductal adenocarcinoma (PDAC) every year. Late diagnosis, together with poor treatment response and resistance to checkpoint inhibitor immunotherapy, contributes to the poor prognosis of the disease. LÄS MER

  4. 3. Roles of membrane vesicles in bacterial pathogenesis

    Författare :Svitlana Vdovikova; Sun Nyunt Wai; Richard Lundmark; Ann-Beth Jonsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Membrane vesicles; autophagy; pore-forming toxin; pore formation; Listeria monocytogenes; Vibrio cholerae; virulence factor; PrtV protease; listeriolysin O; V. cholerae cytolysin; mikrobiologi; Microbiology; molekylärbiologi; Molecular Biology;

    Sammanfattning : The production of membranous vesicles is observed to occur among organisms from all domains of the tree of life spanning prokaryotes (bacteria, archaea) and eukaryotes (plants, animals and fungi). Bacterial release of membrane-derived vesicles (MVs) has been studied most extensively in cases of Gram-negative species and implicating their outer membrane in formation of extracellular MVs. LÄS MER

  5. 4. Gaining influence in standard-setting processes : a discussion of underlying mechanisms in 3G mobile telephony technology development

    Författare :Christina Grundström; Helén Andersson; Linköpings universitet; []
    Nyckelord :Dominant designs; standard-setting processes; 3G mobile telephony technology development; technology and standards hierarchy; industry maturity; roles and functions of people; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP;

    Sammanfattning : The environment in which companies operate is such that standards become increasingly important due to the built-in rigidities resulting from previous technology investments and network externalities. The research question is: How can a market-leading company gain influence on the formation of standards perceived as vital for the company-s continued business? The purpose of the dissertation is to explore, describe, and characterise how such influence may be gained; it thus aims to reveal some of the mechanisms underlying a technology standard-setting process. LÄS MER

  7. 5. The Significance of Spaciousness: an investigation of spaciousness in the context of the residential yard

    Författare :Eva Kristensson; Institutionen för arkitektur och byggd miljö; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; interior design; density; Spaciousness; densification; courtyard; residential yard; open space; Architecture; housing environment; Arkitektur; inredningsarkitektur;

    Sammanfattning : The new interest in density displayed by professional town planners and town-planning researchers is related to the present densification of the urban environment in many towns and cities. Research on densification is primarily concerned with the link between urban form and sustainable development. LÄS MER