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Visar resultat 6 - 10 av 1039 avhandlingar som matchar ovanstående sökkriterier.

  1. 6. Structural and dynamical basis of NusA´s role in transcription-coupled DNA repair

    Författare :Damasus Okeke; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Resonance assignment; DNA repair; transcription-repair coupling factors; transcription-coupled repair; NusA; DinB; UvrD; autoinhibition; DNA substrate; dynamics.;

    Sammanfattning : DNA repair processes involves a host of repair machineries that are able to recognize and repair the damaged DNA. Nucleotide excision repair (NER) pathway is one of these processes exploited by cells to remove bulky DNA lesions. LÄS MER

  3. 7. Induction and repair of clustered DNA damage sites after exposure to ionizing radiation

    Författare :Andris Abramenkovs; Bo Stenerlöw; Peter O'Neill; Uppsala universitet; []
    Nyckelord :NHEJ; DSB repair; clustered DNA damage; DNA repair; DNA-PKcs; HSCS; Ra-223; ionizing radiation; Medicinsk vetenskap; Medical Science;

    Sammanfattning : The mechanisms that maintain genomic stability safeguard cells from constant DNA damage produced by endogenous and external stressors. Therefore, this thesis aimed to specifically address questions regarding the requirement and involvement of DNA repair proteins in the repair of various types of radiation-induced DNA damage. LÄS MER

  4. 8. Radiation response in human cells : DNA damage formation, repair and signaling

    Författare :Ann-Sofie Gustafsson; Bo Stenerlöw; Andrzej Wojcik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionizing radiation; heat-labile sites; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Ionizing radiation induces a range of different DNA lesions. In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). DSB left unrepaired or mis-repaired may result in chromosomal aberrations that can lead to permanent genetic changes or cell death. LÄS MER

  5. 9. Nativelike Performance : A Corpus Study of Pragmatic Markers, Repair and Repetition in Native and Non-native English Speech

    Författare :Annika Denke; Britt Erman; Anna-Brita Stenström; Stockholms universitet; []
    Nyckelord :HUMANIORA; HUMANITIES; fluency; oral presentations; Swedish and native speakers of English; pragmatic markers; repair; repetition; nativelike communicative performance; English language; Engelska språket;

    Sammanfattning : This is a corpus study of native (N) and non-native (NN) communicative performance in speech as realised through pragmatic markers, repair and repetition. The concept of fluency and what it encompasses is discussed in the section dealing with the theoretical background of the study. LÄS MER

  7. 10. Spinal cord repair strategies

    Författare :Henrich Cheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Spinal cord; injury; paraplegia; repair; regeneration; nerve graft; fibrin glue; aFGF; GDNF; gait; axonal tracing Henrich Cheng; 1996;

    Sammanfattning : Regeneration of long fiber tracts does not occur spontaneously in the adult mammalian brain or spinal cord. The present work is an attempt to develop a repair strategy that may overcome this lack of recovery and apply it to spinal cord injury. LÄS MER