Sökning: "heat-labile sites"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden heat-labile sites.

  1. 1. Radiation response in human cells : DNA damage formation, repair and signaling

    Författare :Ann-Sofie Gustafsson; Bo Stenerlöw; Andrzej Wojcik; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionizing radiation; heat-labile sites; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Ionizing radiation induces a range of different DNA lesions. In terms of mutation frequency and mammalian cell survival, the most critical of these lesions is the DNA double-strand break (DSB). DSB left unrepaired or mis-repaired may result in chromosomal aberrations that can lead to permanent genetic changes or cell death. LÄS MER

  3. 2. Role of Non-Homologous End-Joining in Repair of Radiation-Induced DNA Double-Strand Breaks

    Författare :Karin Karlsson; Bo Stenerlöw; Jörgen Carlsson; Thomas Helleday; Uppsala universitet; []
    Nyckelord :Molecular biology; DNA damage; DNA repair; DSB; NHEJ; DNA-PK; ionising radiation; high-LET; heat-labile sites; PFGE; Molekylärbiologi;

    Sammanfattning : Efficient and correct repair of DNA damage, especially DNA double-strand breaks (DSBs), is vital for the survival of individual cells and organisms. Defects in the DNA repair may lead to cell death or genomic instability and development of cancer. LÄS MER

  4. 3. Studies of Carbohydrate-Binding Proteins from Enterotoxigenic Escherichia coli

    Författare :Lena Jansson; Göteborgs universitet; []
    Nyckelord :Carbohydrate recognition; ETEC colonization factors; CFA I fimbriae; CS6 protein; heat-labile enterotoxin;

    Sammanfattning : Knowledge about the carbohydrate binding specificity of pathogens can give an increased understanding of their virulence strategies, and is also of importance for the development of anti-adhesive therapies and vaccines. Enterotoxigenic Escherichia coli (ETEC) is a well-known causative agent of diarrheal disease. LÄS MER

  5. 4. Genetic diversity of the heat labile (LT) and heat stable (ST) toxins of human enterotoxigenic Escherichia coli (ETEC): New insights into polymorphism, regulation, and gene transcription

    Författare :Enrique Joffre; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ETEC; diversity; bacterial enterotoxins; polymorphism; gene regulation; gene transcription; Diarrhoeal disease; bacterial infection;

    Sammanfattning : Infection with enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and travelers to endemic regions. ETEC is a diverse pathogen, with a wide range of virulence factors including enterotoxins and more than 25 identified colonization factors (CFs). LÄS MER

  7. 5. Induction and repair of DNA double-strand breaks in human cells exposed to different radiation qualities

    Författare :Irina Radulescu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DSB; chromatin structure; high-LET; heat-labile sites; PFGE; DNA-PKcs; XRCC1; PARP-1; pATM; gamma-H2AX; 53BP1;

    Sammanfattning : Radiation therapy is used in attempting to kill tumor cells by inducing DNA double- strand breaks (DSB), the most critical DNA lesions. Recent and planned radiation therapy strategies use high-linear energy transfer (LET) radiation to effectively treat malignant tumors. LÄS MER