Sökning: "radial glial cells"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden radial glial cells.

1. 1. Characterization of human dopaminergic neurons in the developing mesencephalon and upon differentiation of stem cells- for replacement therapy in Parkinson´s disease

   Författare :Jenny Nelander Wahlestedt; Utvecklings- och regenerativ neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson´s disease; stem cells; ventral mesencephalon; dopaminergic neurons; cell replacement therapy; human fetal tissue; radial glia; microRNA; BAC recombineering; reporter cell lines;

   Sammanfattning : Cell-replacement therapy is a promising approach for treating patients with Parkinson ́s disease (PD). For this purpose, there is a need for developing a protocol that can generate high numbers of human transplantable mesencephalic dopaminer- gic (mesDA) neurons. LÄS MER

3. 2. EMBRYONIC GLIA AND FOREBRAIN NEUROGENESIS; in vitro generation and differentiation of telencephalic neurons

   Författare :Charlotta Skogh; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; beta tubulin III; GFAP; RC2; Neurology; neuropsychology; neurofysiologi; DARPP-32; retinoic acid; serum; EGF; co-culture; cell culture; striatum; LGE; progenitor; precursor; radial glia; region specific; development; CNS; mouse; human; neurophysiology; Neurologi; neuropsykologi;

   Sammanfattning : The current thesis is aimed to increase our understanding of the generation and differentiation of telencephalic neurons, with emphasis on the role of glial cells in these processes. Using in vitro methods we have studied the role of glial cells in neurogenesis, inheritance of genetic regional specification, and influence on differentiation of neurons. LÄS MER

4. 3. Characterisation of newt neural stem cells during development and regeneration

   Författare :Shahul Hameed Liyakath Ali; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The adult newt brain has a unique potential to regenerate neurons after injury. Ependymoglial cells that line the ventricular system of the newt brain are critical for neuronal regeneration, since they reenter the cell cycle upon injury and differentiate into neurons. Ependymoglial cells share key features with radial glial cells in mammals. LÄS MER

5. 4. Stem cell differentiation, plasticity and regenerative mechanisms in the cholinergic system : implications for Alzheimer’s disease

   Författare :Mats Nilbratt; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Alzheimer´s disease; amyloid precursor protein; cholinergic differentiation; human embryonic stem cells; neural precursor; nicotinic acetylcholine receptor; neurotrophic factor; radial glial cells; transplantation;

   Sammanfattning : Stem cells are immature cells with self-renewal capacity. They are able to differentiate into multiple lineages that may serve as a source of expandable cells for various applications. LÄS MER

7. 5. On the influence of glia on neurite outgrowth from dopamine neurons in the nigrostriatal system

   Författare :Malin Saga Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Dopamine; glia; astrocytes; olfactory ensheathing cells; development; ni-grostriatal; mesencephalon; Parkinson s disease; 6-hydroxydopamine;

   Sammanfattning : Interactions between glial cells and neurons are important during fetal development, in the maintenance of the normal functions in tile central nervous system (CNS), arid in response to injuries or diseases. Some of die motor disturbances in Parkinson's disease, a neurodegenerative disorder where one of the hallmarks is degeneration of dopamine (DA) neurons and concomitant depletion of DA in striatum, can be alleviated by intrastriatal grafting of embryonic DA tissue. LÄS MER