Sökning: "reporter cell lines"

Visar resultat 1 - 5 av 60 avhandlingar innehållade orden reporter cell lines.

  1. 1. p63 – from expression to function : studies of normal oral mucosa and squamous cell carcinoma of the head and neck

    Författare :Niklas Thurfjell; Karin Nylander; Phillip Coates; Göran Roos; Luisa Guerrini; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p63; SCCHN; p53; BRCA1; Pathology; Patologi;

    Sammanfattning : The human p63 gene discovered in 1997 encodes a series of protein isoforms that differ in their N- and/or C-terminal sequences. These isoforms have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis. LÄS MER

  3. 2. The impact of Bcl-3 expression and signaling in cancer

    Författare :Karunakar Saamarthy; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclin D1; BCL3ANT; Colorectal cancer; Melanoma; Prostate cancer; ID; IL-6; Bcl-3;

    Sammanfattning : Bcl-3 is a proto-oncogene and belongs to the inhibitor of κB (IκB) family and is known to be upregulated in numerous cancers. Bcl-3 can initiate transcription of different genes involved in cell survival and cell growth. LÄS MER

  4. 3. Gene therapy of neuroblastoma

    Författare :Yvonne Arvidsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

    Sammanfattning : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. LÄS MER

  5. 4. Method development for the analysis of protein interactions

    Författare :Despoina Kermpatsou; Ola Söderberg; Maréne Landström; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in situ; proximity ligation assay PLA ; strand displacement; proximity-dependent initiation of hybridisation chain reaction proxHCR ; protein complexes; rolling circle amplification RCA ; MolBoolean; vitamin D; 1; 25D3-MARRS receptor; PDIA3; ERp57; CYP24A1; c-Myc; prostate cancer; Molekylär cellbiologi; Molecular Cellbiology; Molekylär medicin; Molecular Medicine;

    Sammanfattning : Biological processes take place through interactions between macromolecules, such as nucleic acids and proteins. It is, therefore, fundamental to understand the functions of proteins and how they form complexes in order to carry out their role. LÄS MER

  7. 5. Bioimaging for analysis of protein expression in cells and tissues using affinity reagents

    Författare :Emma Lundberg; Torbjörn Gräslund; Mathias Uhlén; Rainer Pepperkok; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Affibody; antibody; biomarker; cell line; cell microarray; colorectal cancer; confocal microscopy; HER2; immunohistochemistry; immunofluorescence; light microscopy; protein expression; protein localization; SATB2; tissue microarray; Bioengineering; Bioteknik; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : The detection and analysis of biomolecules, such as proteins, are of great interest since these molecules are fundamental for life and our health. Due to the complexity of biological processes, there is a great advantage of studying proteins in their natural context, for example by using bioimaging. LÄS MER