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Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Effect of quinoline-3-carboxamides on myeloid cells in inflammation and cancer

    Författare :Adnan Deronic; Immunologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Quinoline-3-carboxamide; myeloid cell; inflammation; cancer; peritonitis; mammary carcinoma; fibrosis;

    Sammanfattning : The quinoline-3-carboxamides (Q compounds) are a family of small molecules that ameliorate various types of murine inflammatory autoimmune disease. One such compound has also demonstrated anti-tumor effects in murine tumor models. LÄS MER

  3. 2. Metabolism of quinoline 3-carboxamide compounds, a group of synthetic immunomodulators, in various species

    Författare :Helen Tuvesson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymologi; Proteiner; enzymology; Proteins; Gastroenterologi; Gastro-enterology; pharmacokinetics; enzyme kinetics; quinoline 3-carboxamides; Keywords: Metabolism; cytochrome P450;

    Sammanfattning : Cytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. LÄS MER

  4. 3. S100A9 in inflammatory disease: a potential target for amelioration

    Författare :Sahar Tahvili; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Quinoline-3-carboxamide; Myeloid cell; Type 1 diabetes; Cancer; S100A9;

    Sammanfattning : The quinoline-3-carboxamides (Q compounds) are a family of small molecules with immunomodulatory functions that have shown efficacy in various murine models of inflammatory diseases. One such compound has demonstrated antitumor effects in murine models. Q compounds bind to S100A9, thereby preventing its ligation to TLR4 and RAGE. LÄS MER