Sökning: "protein profile"

Visar resultat 1 - 5 av 439 avhandlingar innehållade orden protein profile.

  1. 1. Protein structure prediction : Zinc-binding sites, one-dimensional structure and remote homology

    Författare :Nanjiang Shu; Sven Hovmöller; Bruce Donald; Geoff Barton; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein structure prediction; zinc-binding; profile; homology detection; shape string; Bioinformatics; Bioinformatik; Molecular biology; Molekylärbiologi; Biochemistry; Biokemi; Structural Chemistry; strukturkemi;

    Sammanfattning : Predicting the three-dimensional (3D) structure of proteins is a central problem in biology. These computationally predicted 3D protein structures have been successfully applied in many fields of biomedicine, e.g. family assignments and drug discovery. LÄS MER

  3. 2. Cotranslational protein biogenesis in Escherichia coli monitored by force profile analysis

    Författare :Felix Nicolaus; Gunnar von Heijne; Ross Dalbey; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; cotranslational protein biogenesis; membrane protein; soluble protein; transmembrane helices; force profile analysis; arrest peptide; biokemi; Biochemistry;

    Sammanfattning : Proteins are a diverse class of biomolecules that carry out many essential functions across all organisms. They can either be found in aqueous compartments or embedded in biological membranes of the cell and are called soluble or membrane proteins, respectively. LÄS MER

  4. 3. From protein sequence to structural instability and disease

    Författare :Lixiao Wang; Uwe Sauer; Sven Hovmöller; Umeå universitet; []
    Nyckelord :protein domain; remote homologue; intrinsically disorder unstructured proteins; protein function; point mutation; protein family protein stability; HMMs; CRFs; SVMs;

    Sammanfattning : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. LÄS MER

  5. 4. Mapping and annotating the mammalian body-wide protein-coding gene expression

    Författare :Max Karlsson; Mathias Uhlén; Linn Fagerberg; Julio Saez-Rodriguez; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein; protein-coding; genes; annotation; atlas; scRNA-Seq; RNA-Seq; transcriptomics; proteomics; Biotechnology; Bioteknologi;

    Sammanfattning : A central aim of fundamental research is to create conditions necessary for fueling further research and innovation. Our understanding of basic biology is central for future developments of tools for diagnosing, monitoring, and treating disease. LÄS MER

  7. 5. Platforms and strategies harnessing signaling pathways of multifactorial diseases by multispecific antibodies

    Författare :Aman Mebrahtu; Johan Rockberg; Fredrik Y. Frejd; Janine Schuurman; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Antibodies; Bispecific antibodies; Multispecific affinity proteins; Protein engineering; Protein expression; Cancer; Immunotherapy; Autoimmunity; Systemic Lupus Erythematosus; Affibody molecules; AffiMab; Antikroppar; Bispecifika antikroppar; Multispecifika affinitets protein; Protein engineering; Protein uttryck; Cancer; Immunoterapai; Autoimmunitet; Systemic Lupus Erythematosus; Affibody molekyler; AffiMab; Biotechnology; Bioteknologi;

    Sammanfattning : Abstract [ENG]Proteins govern a multitude of biological functions vital to sustain life. The ability to withstand diseases development and harboring a defense against foreign pathogens is attributed to the wonders of the immune system and the proteins and cells its comprised of. LÄS MER