Sökning: "Affibody molecules"

Visar resultat 1 - 5 av 49 avhandlingar innehållade orden Affibody molecules.

  1. 1. Affibody Molecules for PET Imaging

    Författare :Joanna Strand; Tolmachev Vladimir; Sten Nilsson; Uppsala universitet; []
    Nyckelord :Affibody molecules; Molecular imaging; PET; Radiolabelling; HER2; PDGFRβ; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Sammanfattning : Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. LÄS MER

  2. 2. Affibody molecules for proteomic and therapeutic applications

    Författare :Caroline Grönwall; Stefan Ståhl; Lena Jendeberg; KTH; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; Affibody; protein engineering; phage display; amyloid beta peptide; transferrin; CD25; IL-2 receptor; proteomics; Bioengineering; Bioteknik;

    Sammanfattning : This thesis describes generation and characterization of Affibody molecules with future applications in proteomics research, protein structure determinations, therapeutic treatment of disease and medical imaging for in vivo diagnostics. Affibody molecules are engineered affinity proteins developed by combinatorial protein engineering from the 58-residue protein A-derived Z domain scaffold. LÄS MER

  3. 3. Cellular Studies of HER-family Specific Affibody Molecules

    Författare :Lovisa Göstring; Lars Gedda; Jörgen Carlsson; Fredrik Frejd; Håkan Hedman; Uppsala universitet; []
    Nyckelord :EGFR; HER2; HER3; Affibody; internalisation; tumour targeting; MEDICINE; MEDICIN;

    Sammanfattning : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. LÄS MER

  4. 4. Generation and characterization of Affibody molecules targeting HER3

    Författare :Magdalena Malm; Stefan Ståhl; Jennifer Cochran; KTH; []
    Nyckelord :Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

    Sammanfattning : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. LÄS MER

  5. 5. Tumour Targeting using Radiolabelled Affibody Molecules : Influence of Labelling Chemistry

    Författare :Mohamed Altai; Vladimir Tolmachev; Jacques Barbet; Uppsala universitet; []
    Nyckelord :HER2; Affibody molecule; Radionuclide molecular maging; Targeted radionuclide therapy; Labeling chemistry;

    Sammanfattning : Affibody molecules are promising candidates for targeted radionuclide-based imaging and therapy applications. Optimisation of targeting properties would permit the in vivo visualization of cancer-specific surface receptors with high contrast. In therapy, this may increase the ratio of radioactivity uptake between tumour and normal tissues. LÄS MER