Sökning: "RNA-Seq"

Visar resultat 1 - 5 av 76 avhandlingar innehållade ordet RNA-Seq.

  1. 1. Integration of RNA and protein expression profiles to study human cells

    Författare :Frida Danielsson; Emma Lundberg; Mikael Huss; Mathias Uhlén; Christine Vogel; KTH; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; RNA-seq; Transcriptomics; Proteomics; Malignant transformation; Cancer; Functional enrichment; Biotechnology; Bioteknologi; Medicinsk teknologi; Medical Technology;

    Sammanfattning : Cellular life is highly complex. In order to expand our understanding of the workings of human cells, in particular in the context of health and disease, detailed knowledge about the underlying molecular systems is needed. LÄS MER

  2. 2. Persistent infection by Yersinia pseudotuberculosis

    Författare :Kemal Avican; Maria Fällman; Wyndham W. Lathem; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Persistent infection; RNA-seq; PMNs; Yersinia; Transcriptome; wrba; fnr; rovA; arcA; rfaH; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar; immunologi; Immunology;

    Sammanfattning : Enteropathogenic Yersinia species can infect many mammalian organs such as the small intestine, cecum, Peyer’s patches, liver, spleen, and lung and cause diseases that resemble a typhoid-like syndrome, as seen for other enteropathogens. We found that sublethal infection doses of Y. LÄS MER

  3. 3. Computational methods for analysis and visualization of spatially resolved transcriptomes

    Författare :Jose Fernandez Navarro; Joakim Lundeberg; Martin Hemberg; KTH; []
    Nyckelord :RNA; RNA-seq; single cell; scRNA-seq; transcriptomics; spatial transcriptomics; brain; 3D; Alzheimer’s disease; Biotechnology; Bioteknologi;

    Sammanfattning : Characterizing the expression level of genes (transcriptome) in cells and tis- sues is essential for understanding the biological processes of multicellular or- ganisms. RNA sequencing (RNA-seq) has gained traction in the last decade as a powerful tool that provides an accurate quantitative representation of the transcriptome in tissues. LÄS MER

  4. 4. Sex, Molecules, and Gene control : Ecophysiological and evolutionary aspects of key sponge species from Antarctic shallow waters and the deep sea

    Författare :Vasiliki Koutsouveli; Paco Cárdenas; Anders Backlund; Ana Riesgo; Cassandra G. Extavour; Uppsala universitet; []
    Nyckelord :Porifera; Demospongiae; Geodia spp.; Phakellia ventilabrum; reproduction; gametogenesis; Antarctica; deep sea; sponge grounds; histology; molecular machinery; electron microscopy; RNA-seq; proteomics; lipidomics; Farmakognosi; Pharmacognosy;

    Sammanfattning : Very little is known about the ecophysiological aspects of Porifera (sponges) from Antarctica and North Atlantic, even though they are keystone components of these habitats. Being the earliest diverging metazoan lineage, sponges also play a fundamental role in our understanding of animal evolution. LÄS MER

  5. 5. Molecular mechanisms of Yersinia pseudotuberculosis for adaptation and establishment of infection in host tissue

    Författare :A. K. M. Firoj Mahmud; Maria Fällman; Matthew S. Francis; Javier Pizarro-Cerda; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; RpoN; T3SS; RNA-Seq; Biofilm; Transcription; Yersinia; Data analysis; ChIP-Seq; biology; biologi;

    Sammanfattning : Bacterial pathogens can evade the host’s immune defence to adapt and establish an infection within the host. Some even slip into a quiescent state to establish themselves without acutely harming the host. Phylogenetically unrelated bacteria can share similar strategies for the establishment of infection and for persistence. LÄS MER