Sökning: "remote homologue"

Hittade 4 avhandlingar innehållade orden remote homologue.

  1. 1. From protein sequence to structural instability and disease

    Författare :Lixiao Wang; Uwe Sauer; Sven Hovmöller; Umeå universitet; []
    Nyckelord :protein domain; remote homologue; intrinsically disorder unstructured proteins; protein function; point mutation; protein family protein stability; HMMs; CRFs; SVMs;

    Sammanfattning : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. LÄS MER

  3. 2. Structural Information and Hidden Markov Models for Biological Sequence Analysis

    Författare :Jeanette Tångrot; Bo Kågström; Uwe H. Sauer; Erik Sonnhammer; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HMM; structure alignment; protein structure; secondary structure; remote homologue; annotation; domain family; protein family; protein superfamily; protein fold recognition; Bioinformatics; Bioinformatik;

    Sammanfattning : Bioinformatics is a fast-developing field, which makes use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins, which is often based on finding relationships to already characterized proteins. LÄS MER

  4. 3. The use of structural information to improve biological sequence similarity searches

    Författare :Jeanette Tångrot; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioinformatik; Hidden Markov Model; HMM; protein structure alignment; protein structure superimposition; remote homologue; FISH-server; protein annotation; Bioinformatics; Bioinformatik;

    Sammanfattning : Bioinformatics is a fast-developing field that make use of computational methods to analyse and structure biological data. An important branch of bioinformatics is structure and function prediction of proteins. To determine the structure of a protein is a crucial part in the characterisation of the molecule. LÄS MER

  5. 4. Functional and bioinformatical studies of the TGFb superfamily : identification and characterization of ALK7

    Författare :Henrik Jörnvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The transforming growth factor beta (TGFbeta) superfamily of polypeptide growth factors encompasses more than 30 diverse mammalian members. They are involved in most cellular processes, ranging from cell proliferation and differentiation, to survival and death. Loss of TGFbeta activity is coupled to tumor development and many other disorders. LÄS MER