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Visar resultat 1 - 5 av 210 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Radiosensitivity in lung cancer with focus on p53

    Författare :Michael Bergqvist; Claes Mercke; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Lung cancer; comet assay; p53; cDNA; p53 antibodies; Lungcancer; Komet metoden; p53 antikroppar; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : In Sweden approximately 2800 new lung cancer patients are diagnosed every year. Radiotherapy is used with curative intention in certain groups of patients. The aim of this thesis is to study the basis of differences in radioresistance and the possibility to predict response to radiotherapy. LÄS MER

  3. 2. Microarray Based Gene Expression Analysis in Cancer Research

    Författare :Cecilia Laurell; Joakim Lundberg; Peter Nilsson; Karin Dahlman-Wright; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenocortical tumour; apoptosis; cancer; classification; gene expression; microarray; p53; RNA amplification; Molecular biology; Molekylärbiologi;

    Sammanfattning : Biotechnological inventions during the 20th century have resulted in a wide range of approaches for explorations in the functional genomics field. Microarray technology is one of the recent advances which have provided us with snapshots of which genes are expressed in cells of various tissues and diseases. LÄS MER

  4. 3. p53 Alterations in Human Skin : A Molecular Study Based on Morphology

    Författare :Ling Gao; Christer Bush Bush; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; p53; skin; mutation; carcinogenesis; microdissection; UV; Basal cell cancer BCC ; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Mutation of the p53 gene appears to be an early event in skin cancer development. The present study is based on morphology and represents a cellular and genetic investigation of p53 alterations in normal human skin and basal cell cancer. LÄS MER

  5. 4. TRIM22/Staf50 - a novel target gene of the tumor suppressor p53

    Författare :Susanna Obad; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematologi; extracellular fluids; Haematology; Medicin människa och djur ; Medicine human and vertebrates ; T lymphocyte; apoptosis; PML; differentiation; hematopoiesis; leukemia; interferon; p53; TRIM22 Staf50; extracellulära vätskor;

    Sammanfattning : The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. LÄS MER

  7. 5. On the function of the interferon-inducible p53 target gene TRIM22

    Författare :Jessica Petersson; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TRIM22; Staf50; p53; IFN; translation; proliferation; cell death;

    Sammanfattning : The interferon-inducible p53-target gene TRIM22 (Staf50) is a member of the TRIM (TRIpartite Motif) family. The TRIM family is a family of RING (Really Interesting New Gene) proteins, defined through a tripartite motif, containing a RING-domain, one or two B-boxes and a Coiled-coil-domain. LÄS MER