Sökning: "p53 gene"
Visar resultat 1 - 5 av 210 avhandlingar innehållade orden p53 gene.
1. Radiosensitivity in lung cancer with focus on p53
Sammanfattning : In Sweden approximately 2800 new lung cancer patients are diagnosed every year. Radiotherapy is used with curative intention in certain groups of patients. The aim of this thesis is to study the basis of differences in radioresistance and the possibility to predict response to radiotherapy. LÄS MER
2. Microarray Based Gene Expression Analysis in Cancer Research
Sammanfattning : Biotechnological inventions during the 20th century have resulted in a wide range of approaches for explorations in the functional genomics field. Microarray technology is one of the recent advances which have provided us with snapshots of which genes are expressed in cells of various tissues and diseases. LÄS MER
3. p53 Alterations in Human Skin : A Molecular Study Based on Morphology
Sammanfattning : Mutation of the p53 gene appears to be an early event in skin cancer development. The present study is based on morphology and represents a cellular and genetic investigation of p53 alterations in normal human skin and basal cell cancer. LÄS MER
4. TRIM22/Staf50 - a novel target gene of the tumor suppressor p53
Sammanfattning : The tumor suppressor gene p53 is a transcription factor that mediates cell cycle arrest, apoptosis and differentiation. p53 mediated differentiation of leukemic cells depends on the transcriptional activity of p53 but so far no obvious differentiation inducing target gene has been identified. LÄS MER
5. On the function of the interferon-inducible p53 target gene TRIM22
Sammanfattning : The interferon-inducible p53-target gene TRIM22 (Staf50) is a member of the TRIM (TRIpartite Motif) family. The TRIM family is a family of RING (Really Interesting New Gene) proteins, defined through a tripartite motif, containing a RING-domain, one or two B-boxes and a Coiled-coil-domain. LÄS MER